Tyck till om SwePub Sök här!
onr:"swepub:oai:DiVA.org:liu-25661"
Sökning: onr:"swepub:oai:DiVA.org:liu-25661" > Membrane transport ...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03258nam a2200301 4500 | |
| 001 | oai:DiVA.org:liu-25661 | |
| 003 | SwePub | |
| 008 | 091008s1992 | |||||||||||000 ||eng| | |
| 020 | a 9178709121q print | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-256612 URI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a dok2 swepub-publicationtype |
| 100 | 1 | a Holm, Ann-Charlotteu Linköpings universitet,Klinisk kemi,Hälsouniversitetet4 aut |
| 245 | 1 0 | a Membrane transport of triiodothyronine :b With particular reference to erythrocytes in health and disease |
| 264 | 1 | a Linköping :b Linköpings universitet,c 1992 |
| 300 | a 45 s. | |
| 338 | a print2 rdacarrier | |
| 490 | 0 | a Linköping University Medical Dissertations,x 0345-0082 ;v 370 |
| 500 | a Papers, included in the Ph.D. thesis, are not registered and included in the posts from 1999 and backwards. | |
| 520 | a Cellular T3 uptake was studied in three human cell systems, i.e. cultured lymphocytes, erythrocytes and erythrocyte membrane vesicles.The basic experimental procedure included 1) incubation of cells or membranes with T3 tracer and increasing concentrations of unlabelled T3, 2) separation of unbound hormone from hormone bound to cells or membranes, 3) counting of radioactivity, and 4) calculation of saturable uptake and uptake constants. Variations on this basic experimental theme included a) addition of ATP or metabolic inhibitors, b) competition by T4 analogues, c) changes of vesicular volume and permeability, and d) changes of membrane temperature. Finally, the T3 concentration in the erythrocytes was measured.The uptake of T3 proved to be carrier-mediated. In lymphocytes it seemed to be energy dependent, but not in erythrocytes, although erythrocyte membrane vesicles had the potential to respond with accelerated uptake to increased energy supply from ATP. The mean Vmax was increased in hyperthyroidism and decreased in hypothyroidism (both p<0.01), and one patient with thyroid hormone resistance had a V max value similar to those of hyperthyroid patients. In patients with low serum free T3 from non-thyroidal causes V max was not altered. The mean Km for T3 uptake in erythrocytes was similar in controls and the patient groups examined.Binding of T3 to the membrane sites occurred only in membranes exposed to 25 °C and subsequently to 0 °C. The mean Bmax thus measured was reduced in hypothyroidism (p<0.05).The mean erythrocyte T3 concentration was 220 pM in healthy subjects, !50 pM in pregnancy, approximately 190 pM in non-thyroidal illnesses and 60 pM in hypothyroidism (all p<0.01).The results show that I) human erythrocytes and lymphocytes take up T3 by carrier-mediated transport, 2) the rate of T3 uptake changes in thyroid diesease but not in pregnancy or nonthyroidal illness, and 3) the erythrocyte T3 concentration is reduced in pregnancy and nonthyroidalillness, as in hypothyroidism. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Nordén, Nils,c Docentu Klinisk Kemiska Laboratoriet, Lasarettet, Lund4 opn |
| 710 | 2 | a Linköpings universitetb Klinisk kemi4 org |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25661 |
Hitta via bibliotek
- Membrane transport of triiodothyronine With particular reference to erythrocytes... (Sök publikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Holm, Ann-Charlo ...
- Nordén, Nils, Do ...
- Delar i serien
- Linköping Univer ...
- Av lärosätet
- Linköpings universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
