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On the prognosis an...
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Rosenberg, PerLinköpings universitet,Onkologi,Hälsouniversitetet
(författare)
On the prognosis and treatment of early stage endometrial carcinoma : Studies with special reference to uterine papillary serous carcinoma
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Linköping :Linköpings universitet,1992
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39 s.
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:liu-25704
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ISBN:9178706467
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25704URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:dok swepub-publicationtype
Serie
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Linköping University Medical Dissertations,0345-0082 ;359
Anmärkningar
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Papers, included in the Ph.D. thesis, are not registered and included in the posts from 1999 and backwards.
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The prognosis and therapy in the subgroup of endometrial malignancies called Uterine Papillary Serous Carcinoma (UPSC) was investigated. This entity constitutes about 6-8 % of all endometrial carcinomas clinical stage I but, as has been shown here, accounts for one third of the cancer mortality in the early stages of endometrial carcinoma.-The prognostic significance of nuclear atypia, FIGO grade and age was determined in patients with clinical stage 1-11 Uterine Papillary Serous Carcinoma.-DNA-index and S-phase fraction, determined by flow cytometry on formalin-fixed, paraffin-embedded endometrial curettage material was evaluated in relation to nuclear atypia, FIGO grade and age in early stage endometrial carcinoma.-A new method of minimizing the dilution of non-epithelial cells in the malignant curettage material when performing flow cytometry was developed.-The survival and pattern of metastasis in a population-based patient material was investigated -The effects on survival of a new aggressive treatment regimen was assessed.The results show that: Patients with uterine papillary serous carcinoma have a much worse prognosis than do patients with ordinary endometrial carcinoma.DNA ploidy and S-phaseratederived from flow cytometryperformed on disintegrated, previously paraffinembedded, endometrial curettings are important prognostic factors.It is possible to exclude contaminating non-epithelial cells from the DNA analysis by the use of an anticytokeratin antibody, Patients with uterine papillary serous carcinoma clinical stage I have a significantly higher risk of recurrence than patients with non-UPSC. The localisation of the recurrences among the UPSC patients is more similar to that of serous papillary ovarian carcinoma than that of ordinary adenocarcinoma of the endometrium. A primary treatment ofUPSC with a more extensive surgery, adjuvant external radiation and platinum-based chemotherapy seems to improve the outcome.
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Sorbe, Bengt,DocentÖrebro
(opponent)
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Linköpings universitetOnkologi
(creator_code:org_t)
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