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Kantor, Elizabeth D.Department of Epidemiology, Harvard School of Public Health, Boston, USA
(författare)
Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2015-05-18
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London, United Kingdom :BMJ Publishing Group,2016
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LIBRIS-ID:oai:DiVA.org:oru-44822
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-44822URI
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https://doi.org/10.1136/gutjnl-2014-309007DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133934644URI
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Språk:engelska
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Sammanfattning på:engelska
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Funding Agencies:National Cancer Institute T32 CA 009001Harvard School of Public HealthÖrebro University Strategic FundingUK Economic and Social Research Council (ESRC) RES-596-28-0001 ES/JO19119/1
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Objective: Adult obesity and inflammation have been associated with risk of colorectal cancer (CRC); however, less is known about how adolescent body mass index (BMI) and inflammation, as measured by erythrocyte sedimentation rate (ESR), relate to CRC risk. We sought to evaluate these associations in a cohort of 239 658 Swedish men who underwent compulsory military enlistment examinations in late adolescence (ages 16-20 years).Design: At the time of the conscription assessment (1969-1976), height and weight were measured and ESR was assayed. By linkage to the national cancer registry, these conscripts were followed for CRC through 1 January 2010. Over an average of 35 years of follow-up, 885 cases of CRC occurred, including 501 colon cancers and 384 rectal cancers. Cox regression was used to estimate adjusted HRs and corresponding 95% CIs.Results: Compared with normal weight (BMI 18.5 to <25 kg/m(2)) in late adolescence, upper overweight (BMI 27.5 to <30 kg/m(2)) was associated with a 2.08-fold higher risk of CRC (95% CI 1.40 to 3.07) and obesity (BMI 30+ kg/m(2)) was associated with a 2.38-fold higher risk of CRC (95% CI 1.51 to 3.76) (p-trend: <0.001). Male adolescents with ESR (15+ mm/h) had a 63% higher risk of CRC (HR 1.63; 95% CI 1.08 to 2.45) than those with low ESR (<10 mm/h) (p-trend: 0.006). Associations did not significantly differ by anatomic site.Conclusions: Late-adolescent BMI and inflammation, as measured by ESR, may be independently associated with future CRC risk. Further research is needed to better understand how early-life exposures relate to CRC.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Udumyan, Ruzan,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics(Swepub:oru)run
(författare)
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Signorello, Lisa B.Department of Epidemiology, Harvard School of Public Health, Boston, USA
(författare)
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Giovannucci, Edward L.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, USA
(författare)
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Montgomery, Scott,1961-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Research Department of Epidemiology and Public Health, University College London, London, United Kingdom; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics(Swepub:oru)smy
(författare)
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Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Epidemiology, Harvard School of Public Health, Boston, USA; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics(Swepub:oru)kafl
(författare)
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Department of Epidemiology, Harvard School of Public Health, Boston, USAInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:GutLondon, United Kingdom : BMJ Publishing Group65:8, s. 1289-12950017-57491468-3288
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