Obsessive-compulsive disorder, serotonin and oxytocin: treatment response and side effects

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MARC

Humble, Mats B.,1952-Örebro universitet,Institutionen för medicinska vetenskaper (author)

Obsessive-compulsive disorder, serotonin and oxytocin : treatment response and side effects

BookEnglish2016

Publisher, publication year, extent ...

Örebro :Örebro university,2016
133 s.
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:oru-51438
ISBN:9789175291536
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51438URI

Supplementary language notes

Language:English
Summary in:English

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SwePubSwePub

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Subject category:vet swepub-contenttype
Subject category:dok swepub-publicationtype

Series

Örebro Studies in Medicine,1652-4063 ;148

Notes

Obsessive-compulsive disorder (OCD), with a prevalence of 1-2 %, frequently leads a chronic course. Persons with OCD are often reluctant to seek help and, if they do, their OCD is often missed. This is unfortunate, since active treatment may substantially improve social function and quality of life. Serotonin reuptake inhibitors (SRIs) have welldocumented efficacy in OCD, but delayed response may be problematic. Methods to predict response have been lacking. Because SRIs are effective, pathophysiological research on OCD has focussed on serotonin. However, no clear aberrations of serotonin have been found, thus other mechanisms ought to be involved.Our aims were to facilitate clinical detection and assessment of OCD, to search for biochemical correlates of response and side-effects in SRI treatment of OCD and to identify any possible involvement of oxytocin in the pathophysiology of OCD.In study I, we tested in 402 psychiatric out-patients the psychometric properties of a concise rating scale, “Brief Obsessive Compulsive Scale” (BOCS). BOCS was shown to be easy to use and have excellent discriminant validity in relation to other common psychiatric diagnoses.Studies II-V were based on 36 OCD patients from a randomised controlled trial of paroxetine, clomipramine or placebo. In study II, contrary to expectation, we found that the change (decrease) of serotonin in whole blood was most pronounced in non-responders to SRI. This is likely to reflect inflammatory influence on platelet turnover rather than serotonergic processes within the central nervous system.In studies IV-V, we found relations between changes of oxytocin in plasma and the anti-obsessive response, and between oxytocin and the SRI related delay of orgasm, respectively. In both cases, the relation to central oxytocinergic mechanisms is unclear. In males, delayed orgasm predicted anti-obsessive response.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
Adverse effects
Obsessive-compulsive disorder
Orgasm
Oxytocin
Randomised controlled trial
Rating scale
Response prediction
Serotonin
Serotonin uptake inhibitors
Sexual function
Psychiatry
Psykiatri

Added entries (persons, corporate bodies, meetings, titles ...)

Engström, Ingemar,Adjungerad professorÖrebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)iem (thesis advisor)
von Knorring, Lars,ProfessorUppsala universitet (thesis advisor)
Kjellin, Lars,DocentÖrebro universitet,Institutionen för hälsovetenskaper(Swepub:oru)lkn (thesis advisor)
Träskman-Bendz, Lil,ProfessorInstitutionen för kliniska vetenskaper, Lunds universitet (opponent)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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