Population structure of Neisseria gonorrhoeae based on whole genome data and its relationship with antibiotic resistance

Ezewudo, Matthew N.Sch Med, Dept Med, Div Infect Dis, Emory Univ, Atlanta GA, USA (författare)

Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection (STI) of major importance. As a result of antibiotic resistance, there are now limited options for treating patients. We collected draft genome sequence data and associated metadata data on 76 N. gonorrhoeae strains from around the globe and searched for known determinants of antibiotics resistance within the strains. The population structure and evolutionary forces within the pathogen population were analyzed. Our results indicated a cosmopolitan gonoccocal population mainly made up of five subgroups. The estimated ratio of recombination to mutation (r/m = 2.2) from our data set indicates an appreciable level of recombination occurring in the population. Strains with resistance phenotypes to more recent antibiotics (azithromycin and cefixime) were mostly found in two of the five population subgroups.

Joseph, Sandeep J.Sch Med, Dept Med, Div Infect Dis, Emory Univ, Atlanta GA, USA (författare)
Castillo-Ramirez, SantiagoCtr Ciencias Genom, Programa Genom Evolut, Univ Nacl Autonoma Mexico, Cuernavaca, Mexico (författare)
Dean, DeborahOakland Res Inst, Childrens Hosp, Oakland CA, USA; Div Infect Dis, Univ Calif, San Francisco CA, USA (författare)
del Rio, CarlosSch Med, Dept Med, Div Infect Dis, Emory Univ, Atlanta GA, USA; Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Emory Univ, Atlanta GA, USA (författare)
Didelot, XavierSci Technol & Med, Dept Infect Dis Epidemiol, Univ London Imperial College, London, England (författare)
Dillon, Jo-AnneColl Med, Dept Microbiol & Immunol, Vaccine & Infect Dis Org Int Vaccine Ctr, Univ Saskatchewan, Saskatoon SK, Canada (författare)
Selden, Richard F.NetBio, Waltham MA, USA (författare)
Shafer, William M.Sch Med, Dept Microbiol & Immunol, Emory Univ, Atlanta GA, USA; Labs Bacterial Pathogenesis, Vet Affairs Med Ctr, Decatur GA, USA (författare)
Turingan, Rosemary S.NetBio, Waltham MA, USA (författare)
Unemo, MagnusRegion Örebro län,WHO Collaborating Ctr Gonorrhoea & Other STIs, Örebro University Hospital, Örebro, Sweden(Swepub:oru)muo (författare)
Read, Timothy D.Sch Med, Dept Med, Div Infect Dis, Emory Univ, Atlanta GA, USA (författare)
Sch Med, Dept Med, Div Infect Dis, Emory Univ, Atlanta GA, USACtr Ciencias Genom, Programa Genom Evolut, Univ Nacl Autonoma Mexico, Cuernavaca, Mexico (creator_code:org_t)

Av författaren/redakt...: Ezewudo, Matthew ...; Joseph, Sandeep ...; Castillo-Ramirez ...; Dean, Deborah; del Rio, Carlos; Didelot, Xavier; visa fler...; Dillon, Jo-Anne; Selden, Richard ...; Shafer, William ...; Turingan, Rosema ...; Unemo, Magnus; Read, Timothy D.; visa färre...

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