onr:"swepub:oai:DiVA.org:oru-56748"
Sökning: onr:"swepub:oai:DiVA.org:oru-56748" > A study of docetaxe...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Sorbe, BengtRegion Örebro län,Dept Oncol, Örebro University Hospital, Örebro, Sweden (författare)
A study of docetaxel weekly or every three weeks in combination with carboplatin as first line chemotherapy in epithelial ovarian cancer : Hematological and non-hematological toxicity profiles
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
- 2013-01-22
- Spandidos Publications,2013
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-56748
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56748URI
- https://doi.org/10.3892/ol.2013.1146DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- The purpose of this study was to compare the toxicity profiles of docetaxel administered on a weekly schedule and the standard three-week schedule in the treatment of advanced primary ovarian carcinoma. Eligible patients were treated with intravenous docetaxel (30 mg/m(2)) on days 1, 8 and 15, and carboplatin (AUC 5) on day 1 or with docetaxel (75 mg/m(2)) and carboplatin (AUC 5) on day 1; Q21 days for 6 cycles. This study was a pooled study of two primary phase II studies. A total of 108 patients received the weekly schedule and 59 patients received the three-week schedule. All patients were evaluated for toxicity. The overall response rate was 79% and the biochemical response 93% for the weekly schedule. The median overall survival rate was 35.3 months. Neutropenia was significantly more common (ANOVA; p<0.0001) in the three-week group than in the weekly group during all six courses of chemotherapy. Fever and infections were also more common in this group. Thrombocytopenia and anemia were slightly more common in the weekly group. Fatigue, epiphora, nail changes and taste disturbances were specific side-effects following weekly docetaxel. Peripheral sensory neuropathy (grade 1-2) increased with every cycle of treatment, but in a similar manner in the two groups. Grade 3-4 neuropathy was not recorded. Oral mucositis and myalgia were two side-effects associated with the three-week schedule. Nausea and vomiting, diarrhea and dyspnea were a limited problem in both groups. Cardiac toxicity was rare and did not differ between the two docetaxel schedules. The weekly administration was favored due to the lower rates of neutropenia, fever, infections, oral mucositis and myalgia. However, epiphora and nail changes were specific side-effects of the weekly treatment. Both regimens appeared to be rather well tolerated with similar compliance (66 and 70%) with regard to completion of the planned six courses of chemotherapy.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- ovarian cancer
- docetaxel
- carboplatin
- weekly administration
- 3-week administration
- hematological toxicity
- non-hematological toxicity
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Graflund, MarianneDept Oncol, Örebro University Hospital, Örebro, Sweden (författare)
- Nygren, LisaDept Oncol, Örebro University Hospital, Örebro, Sweden (författare)
- Horvath, GyorgyDept Oncol, Sahlgrenska Univ Hosp, Gothenburg, Sweden (författare)
- Region Örebro länDept Oncol, Örebro University Hospital, Örebro, Sweden (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Oncology Letters: Spandidos Publications5:4, s. 1140-11481792-10741792-1082
Internetlänk
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Sorbe, Bengt
- Graflund, Marian ...
- Nygren, Lisa
- Horvath, Gyorgy
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
- Artiklar i publikationen
- Oncology Letters
- Av lärosätet
- Örebro universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
