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A study of serum bi...
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Bohr Mordhorst, Louise,1958-Region Örebro län
(författare)
A study of serum biomarkers associated with relapse of cervical cancer
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-56898
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56898URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND/AIM: To discover candidate protein biomarkers in the serum of patients with cervical cancer that differentiate between patients with relapse from those who are tumor-free after primary treatment with (platinum-based chemo-) radiation.PATIENTS AND METHODS: Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) with cation exchange (CM10) and hydrophobic/reverse-phase (H50) was used to examine 44 serum samples from patients with advanced cervical cancer, primarily treated with (platinum-based chemo-) radiation.RESULTS: Ten candidate biomarkers were identified in the serum of 34 patients. Six candidate markers were elevated in patients with no relapse and four were elevated in patients with relapse [p=0.007-0.11; area under the curve (AUC)=0.70-0.75]. Masses of candidate biomarkers ranged from 2,022 to 116,165 Da.CONCLUSION: Patients with relapse from primary advanced cervical cancer exhibit different serum protein expression profiles from those with no relapse.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sorbe, BengtRegion Örebro län(Swepub:oru)bse
(författare)
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Ahlin, CeciliaDepartment of Oncology, Örebro University Hospital, Örebro, Sweden
(författare)
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Region Örebro länDepartment of Oncology, Örebro University Hospital, Örebro, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Anticancer Research32:11, s. 4913-220250-70051791-7530
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