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O'Gorman, A.Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland; Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin (UCD) Belfield, Dublin, Ireland
(författare)
Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-09-26
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Nature Publishing Group,2017
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-61635
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-61635URI
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https://doi.org/10.1038/tp.2017.211DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:Wellcome 102215/2/13/2 NIHR Bristol BRC Irish Health Research Board through a Clinician Scientist Award Health Research Board HRA-POR-2013-282 HRB CSA 2012/8 European Research Council 647783 UK Medical Research Council 102215/2/13/2
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The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and lipidomic approaches in combination with multivariate statistical analysis were applied to identify plasma alterations in children (age 11) (38 cases vs 67 controls) and adolescents (age 18) (36 cases vs 117 controls) preceeding or coincident with the development of psychotic disorder (PD) at age 18 in the Avon Longitudinal Study of Parents and Children (ALSPAC). Overall, 179 lipids were identified at age 11, with 32 found to be significantly altered between the control and PD groups. Following correction for multiple comparisons, 8 of these lipids remained significant (lysophosphatidlycholines (LPCs) LPC(18: 1), LPC(18: 2), LPC(20: 3); phosphatidlycholines (PCs) PC(32: 2; PC(34: 2), PC(36: 4), PC(0-34-3) and sphingomyelin (SM) SM(d18: 1/24: 0)), all of which were elevated in the PD group. At age 18, 23 lipids were significantly different between the control and PD groups, although none remained significant following correction for multiple comparisons. In conclusion, the findings indicate that the lipidome is altered in the blood during childhood, long before the development of psychotic disorder. LPCs in particular are elevated in those who develop PD, indicating inflammatory abnormalities and altered phospholipid metabolism. These findings were not found at age 18, suggesting there may be ongoing alterations in the pathophysiological processes from prodrome to onset of PD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Suvitaival, T.Steno Diabetes Center, Gentofte, Denmark
(författare)
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Ahonen, L.Steno Diabetes Center, Gentofte, Denmark
(författare)
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Cannon, M.Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland
(författare)
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Zammit, S.Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK; Centre for Academic Mental Health, School of Social & Community Medicine, University of Bristol, Bristol, UK
(författare)
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Lewis, G.Division of Psychiatry, University College London, London, UK
(författare)
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Roche, H. M.Nutrigenomics Research Group, UCD Conway Institute/UCD Institute of Food & Health, School of Public Health, Physiotherapy & Sports Science, University College Dublin (UCD) Belfield, Dublin, Ireland
(författare)
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Mattila, I.Steno Diabetes Center, Gentofte, Denmark
(författare)
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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Steno Diabetes Center, Gentofte, Denmark,Department of Chemistry(Swepub:oru)tihn
(författare)
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Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Steno Diabetes Center, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku, Turku, Finland; Åbo Akademi University, Turku, Finland(Swepub:oru)moc
(författare)
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Brennan, L.Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin (UCD) Belfield, Dublin, Ireland
(författare)
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Cotter, D. R.Department of Psychiatry, Beaumont Hospital, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland
(författare)
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Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland; Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin (UCD) Belfield, Dublin, IrelandSteno Diabetes Center, Gentofte, Denmark
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Translational Psychiatry: Nature Publishing Group72158-3188
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Till lärosätets databas
- Av författaren/redakt...
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O'Gorman, A.
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Suvitaival, T.
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Ahonen, L.
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Cannon, M.
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Zammit, S.
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Lewis, G.
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visa fler...
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Roche, H. M.
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Mattila, I.
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Hyötyläinen, Tuu ...
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Oresic, Matej, 1 ...
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Brennan, L.
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Cotter, D. R.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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Translational Ps ...
- Av lärosätet
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Örebro universitet