Marital status, telomere length and cardiovascular disease risk in a Swedish prospective cohort

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Chen, RuoqingKarolinska Institutet (author)

Marital status, telomere length and cardiovascular disease risk in a Swedish prospective cohort

Article/chapterEnglish2020

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2019-11-14
BMJ Publishing Group Ltd,2020
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LIBRIS-ID:oai:DiVA.org:oru-77941
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77941URI
https://doi.org/10.1136/heartjnl-2019-315629DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:143129018URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agency:Karolinska Institutet (the Strategic Research Area in Epidemiology)
OBJECTIVE: To investigate if marital status is associated with risk of cardiovascular disease (CVD) and to explore the potential influence of leucocyte telomere length (LTL), a marker of biological ageing, on such association.DESIGN: Population-based prospective cohort study SETTINGS: Swedish Twin Registry.PARTICIPANTS: Based on the Screening Across the Lifespan Twin Study from the Swedish Twin Registry, we included 10 058 twins born between 1900 and 1958 who underwent an interview between 1998 and 2002 during which information about marital status was collected. Blood samples from these participants were subsequently collected between 2004 and 2008 and used for LTL assessment using quantitative PCR technique.MAIN OUTCOME MEASURES: Incident cases of CVD were identified through the Swedish Patient Register and Causes of Death Register through December 31, 2016. Multivariable linear regression and Cox proportional hazards regression models were used to estimate the regression coefficients (βs) and HRs with 95% CIs respectively. Potential confounders included age, sex, educational attainment and body mass index.RESULTS: A total of 2010 participants were diagnosed with CVD during a median follow-up of 9.8 years. LTL was shorter among individuals living singly, including those who were divorced or separated (β:-0.014, 95% CI: -0.035, 0.007), widowed (β:-0.035, 95% CI: -0.061, -0.010), or living alone (β:-0.033, 95% CI: -0.052, -0.014), than individuals who were married or cohabitating. One SD increase of LTL was associated with a lower risk of CVD (HR: 0.79, 95% CI: 0.66, 0.93). Individuals who were divorced or separated, widowed, or living alone had a higher risk of CVD than individuals who were married or cohabitating. The summary HR of CVD was 1.21 (95% CI: 1.08, 1.35) when comparing individuals who were living singly, regardless of reason, with the individuals who were married or cohabitating. LTL appeared to mediate little of the association between marital status and CVD (HR additionally adjusted for LTL: 1.20; 95% CI: 1.08, 1.34).CONCLUSIONS: Living singly, regardless of reason, was associated with a shorter LTL and a higher risk of CVD. The association between marital status and CVD was however not greatly attributable to telomere shortening.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Cardiac risk factors and prevention
epidemiology
quality and outcomes of care

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Zhan, YiqiangKarolinska Institutet (author)
Pedersen, NancyKarolinska Institutet (author)
Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)kafl (author)
Valdimarsdóttir, Unnur A.Karolinska Institutet (author)
Hägg, SaraKarolinska Institutet (author)
Fang, FangKarolinska Institutet (author)
Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:Heart: BMJ Publishing Group Ltd106:4, s. 267-2721355-60371468-201X

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By the author/editor: Chen, Ruoqing; Zhan, Yiqiang; Pedersen, Nancy; Fall, Katja, 197 ...; Valdimarsdóttir, ...; Hägg, Sara; show more...; Fang, Fang; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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By the university: Örebro University; Karolinska Institutet

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