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A metabolite-based ...
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Stamate, DanielDivision of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, UK; Data Science & Soft Computing Lab, London, UK; Computing Department, Goldsmiths College, University of London, London, UK
(författare)
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-01
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John Wiley & Sons,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-79714
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79714URI
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https://doi.org/10.1016/j.trci.2019.11.001DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:231890857URI
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https://gup.ub.gu.se/publication/288483URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding: The present study was conducted as part of the EMIF‐AD project, which has received support from the Innovative Medicines Initiative Joint Undertaking under EMIF grant agreement no. 115372, resources of which are composed of financial contribution from the European Union's Seventh Framework Program (FP7/2007–2013) and EFPIA companies' in‐kind contribution. The DESCRIPA study was funded by the European Commission within the fifth framework program (QLRT‐2001‐2455). The EDAR study was funded by the European Commission within the fifth framework program (contract no. 37670). The San Sebastian GAP study is partially funded by the Department of Health of the Basque Government (allocation 17.0.1.08.12.0000.2.454.01. 41142.001.H). Kristel Sleegers is supported by the Research Fund of the University of Antwerp. Daniel Stamate is supported by the Alzheimer's Research UK (ARUK‐PRRF2017‐012).
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IntroductionMachine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers.MethodsThis study analyzed samples from 242 cognitively normal (CN) people and 115 with AD‐type dementia utilizing plasma metabolites (n = 883). Deep Learning (DL), Extreme Gradient Boosting (XGBoost) and Random Forest (RF) were used to differentiate AD from CN. These models were internally validated using Nested Cross Validation (NCV).ResultsOn the test data, DL produced the AUC of 0.85 (0.80–0.89), XGBoost produced 0.88 (0.86–0.89) and RF produced 0.85 (0.83–0.87). By comparison, CSF measures of amyloid, p‐tau and t‐tau (together with age and gender) produced with XGBoost the AUC values of 0.78, 0.83 and 0.87, respectively.DiscussionThis study showed that plasma metabolites have the potential to match the AUC of well‐established AD CSF biomarkers in a relatively small cohort. Further studies in independent cohorts are needed to validate whether this specific panel of blood metabolites can separate AD from controls, and how specific it is for AD as compared with other neurodegenerative disorders.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kim, MinSteno Diabetes Center Copenhagen, Gentofte, Denmark
(författare)
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Proitsi, PetroulaInstitute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
(författare)
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Weestwood, SarahDepartment of Psychiatry, University of Oxford, Oxford, UK
(författare)
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Baird, AlisonDepartment of Psychiatry, University of Oxford, Oxford, UK
(författare)
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Nevado-Holgado, AlejoDepartment of Psychiatry, University of Oxford, Oxford, UK
(författare)
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Hye, AbdulInstitute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
(författare)
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Bos, IsabelleDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
(författare)
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Vos, Stephanie J.B.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
(författare)
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Vandenberghe, RikDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
(författare)
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Teunissen, Charlotte E.Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands
(författare)
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Kate, Mara TenDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands
(författare)
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Scheltens, PhilipDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
(författare)
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Gabel, SilvyDepartment of Clinical Chemistry, Neurochemistry Laboratory, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit, the Netherlands; University Hospital Leuven, Leuven, Belgium; Department of Neurosciences, Laboratory for Cognitive Neurology, KU, Leuven, Belgium
(författare)
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Meersmans, KarenUniversity Hospital Leuven, Leuven, Belgium; Department of Neurosciences, Laboratory for Cognitive Neurology, KU, Leuven, Belgium
(författare)
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Blin, OlivierAIX Marseille University, INS, Ap‐hm, Marseille, France
(författare)
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Richardson, JillNeurosciences Therapeutic Area GlaxoSmithKline R&D, Stevenage, UK
(författare)
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De Roeck, EllenFaculty of Psychology & Educational Sciences Vrije, Universiteit Brussel (VUB), Brussels, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium
(författare)
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Engelborghs, SebastiaanReference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology, UZ Brussel and Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium
(författare)
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Sleegers, KristelInstitute Born‐Bunge, University of Antwerp, Antwerp, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Belgium
(författare)
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Bordet, RégisUniversity of Lille, Inserm, CHU Lille, Lille, France
(författare)
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Ramit, LorenaAlzheimer's Disease & Other Cognitive Disorders Unit, Hospital Clínic‐IDIBAPS, Barcelona, Spain
(författare)
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Kettunen, PetronellaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xketpe
(författare)
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Tsolaki, Magda1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece
(författare)
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Verhey, FransDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
(författare)
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Alcolea, DanielMemory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
(författare)
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Lléo, AlbertoMemory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
(författare)
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Peyratout, GwemdolineUniversity Hospital of Lausanne, Lausanne, Switzerland
(författare)
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Tainta, MikaelCenter for Research and Advanced Therapies, Fundacion CITA‐alzheimer Fundazioa, Donostia/San Sebastian, Spain
(författare)
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Johannsen, PeterDanish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
(författare)
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Freund-Levi, Yvonne,1956-Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institute, Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden(Swepub:oru)yfi
(författare)
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Frölich, LutzDepartment of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany
(författare)
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Dobricic, ValerijaLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany
(författare)
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Frisoni, Giovanni B.University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
(författare)
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Molinuevo, José L.University of Lille, Inserm, CHU Lille, Lille, France; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
(författare)
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Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xwaand
(författare)
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Popp, JuliusUniversity Hospital of Lausanne, Lausanne, Switzerland; Department of Mental Health and Psychiatry, Geriatric Psychiatry, Geneva University Hospitals, Geneva, Switzerland
(författare)
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Martinez-Lage, PabloCenter for Research and Advanced Therapies, Fundacion CITA‐alzheimer Fundazioa, Donostia/San Sebastian, Spain
(författare)
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Bertram, LarsLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway
(författare)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(författare)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(författare)
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Streffer, JohannesReference Center for Biological Markers of Dementia (BIODEM), Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium
(författare)
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Visser, Pieter J.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
(författare)
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Lovestone, SimonDepartment of Psychiatry, University of Oxford, Oxford, UK; Janssen‐Cilag UK Ltd, Oxford, UK
(författare)
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Legido-Quigley, ChristinaSteno Diabetes Center Copenhagen, Gentofte, Denmark; Institute of Pharmaceutical Science, King's College London, London, UK
(författare)
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Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, UK; Data Science & Soft Computing Lab, London, UK; Computing Department, Goldsmiths College, University of London, London, UKSteno Diabetes Center Copenhagen, Gentofte, Denmark
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Alzheimer’s & Dementia: John Wiley & Sons5:C, s. 933-9382352-8737
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Stamate, Daniel
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Kim, Min
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Proitsi, Petroul ...
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Weestwood, Sarah
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Baird, Alison
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Nevado-Holgado, ...
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Hye, Abdul
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Bos, Isabelle
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Vos, Stephanie J ...
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Vandenberghe, Ri ...
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Teunissen, Charl ...
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Kate, Mara Ten
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Scheltens, Phili ...
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Gabel, Silvy
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Meersmans, Karen
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Blin, Olivier
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Richardson, Jill
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De Roeck, Ellen
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Engelborghs, Seb ...
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Sleegers, Kriste ...
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Bordet, Régis
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Ramit, Lorena
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Kettunen, Petron ...
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Tsolaki, Magda
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Verhey, Frans
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Alcolea, Daniel
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Lléo, Alberto
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Peyratout, Gwemd ...
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Tainta, Mikael
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Johannsen, Peter
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Freund-Levi, Yvo ...
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Frölich, Lutz
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Dobricic, Valeri ...
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Frisoni, Giovann ...
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Molinuevo, José ...
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Wallin, Anders, ...
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Popp, Julius
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Martinez-Lage, P ...
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Bertram, Lars
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Streffer, Johann ...
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Visser, Pieter J ...
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