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- Ke, Rongqin (author)
Fourth Generation of Next-Generation Sequencing Technologies : Promise and Consequences
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016-08-10
- Hindawi Limited,2016
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-137595
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-137595URI
- https://doi.org/10.1002/humu.23051DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-313615URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- In this review, we discuss the emergence of the fourth-generation sequencing technologies that preserve the spatial coordinates of RNA and DNA sequences with up to subcellular resolution, thus enabling back mapping of sequencing reads to the original histological context. This information is used, for example, in two current large-scale projects that aim to unravel the function of the brain. Also in cancer research, fourth-generation sequencing has the potential to revolutionize the field. Cancer Research UK has named Mapping the molecular and cellular tumor microenvironment in order to define new targets for therapy and prognosis one of the grand challenges in tumor biology. We discuss the advantages of sequencing nucleic acids directly in fixed cells over traditional next-generation sequencing (NGS) methods, the limitations and challenges that these new methods have to face to become broadly applicable, and the impact that the information generated by the combination of in situ sequencing and NGS methods will have in research and diagnostics.
Subject headings and genre
- NATURVETENSKAP Data- och informationsvetenskap Bioinformatik hsv//swe
- NATURAL SCIENCES Computer and Information Sciences Bioinformatics hsv//eng
- NATURVETENSKAP Biologi Bioinformatik och systembiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Bioinformatics and Systems Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- next-generation sequencing
- in situ sequencing
- single cell sequencing
- spatial gene expression
- multiplex in situ RNA detection
- Datoriserad bildbehandling
Added entries (persons, corporate bodies, meetings, titles ...)
- Mignardi, MarcoUppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion(Swepub:uu)marmi748 (author)
- Hauling, ThomasStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)thha3442 (author)
- Nilsson, MatsStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)matsn (author)
- Uppsala universitetAvdelningen för visuell information och interaktion (creator_code:org_t)
Related titles
- In:Human Mutation: Hindawi Limited37:12, s. 1363-13671059-77941098-1004
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