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GalR3 activation pr...
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Mansouri, ShivaKarolinska Institutet,Karolinska institutet
(författare)
GalR3 activation promotes adult neural stem cell survival in response to a diabetic milieu
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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2013-09-03
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Wiley,2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:su-95761
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-95761URI
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https://doi.org/10.1111/jnc.12396DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127496888URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-38212URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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AuthorCount:9;
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Type 2 diabetes impairs adult neurogenesis which could play a role in the CNS complications of this serious disease. The goal of this study was to determine the potential role of galanin in protecting adult neural stem cells (NSCs) from glucolipotoxicity and to analyze whether apoptosis and the unfolded protein response were involved in the galanin-mediated effect. We also studied the regulation of galanin and its receptor subtypes under diabetes in NSCs in vitro and in the subventricular zone (SVZ) in vivo. The viability of mouse SVZ-derived NSCs and the involvement of apoptosis (Bcl-2, cleaved caspase-3) and unfolded protein response [C/EBP homologous protein (CHOP) Glucose-regulated protein 78/immunoglobulin heavy-chain binding protein (GRP78/BiP), spliced X-box binding protein 1 (XBP1), c-Jun N-terminal kinases (JNK) phosphorylation] were assessed in the presence of glucolipotoxic conditions after 24h. The effect of diabetes on the regulation of galanin and its receptor subtypes was assessed on NSCs in vitro and in SVZ tissues isolated from normal and type 2 diabetes ob/ob mice. We show increased NSC viability following galanin receptor (GalR)3 activation. This protective effect correlated with decreased apoptosis and CHOP levels. We also report how galanin and its receptors are regulated by diabetes in vitro and in vivo. This study shows GalR3-mediated neuroprotection, supporting a potential future therapeutic development, based on GalR3 activation, for the treatment of brain disorders.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Barde, SwapnaliKarolinska Institutet,Karolinska institutet
(författare)
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Ortsäter, HenrikKarolinska institutet
(författare)
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Eweida, MohamedSödersjukhuset
(författare)
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Darsalia, VladimerKarolinska Institutet,Karolinska institutet
(författare)
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Langel, ÜloStockholms universitet,Institutionen för neurokemi,Stockholms universitet, Institutionen för neurokemi(Swepub:su)ulo
(författare)
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Sjöholm, ÅkeKarolinska institutet; University of South Alabama, AL, USA(Swepub:hig)akesjm
(författare)
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Hökfelt, TomasKarolinska Institutet,Karolinska institutet
(författare)
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Patrone, CesareKarolinska Institutet,Karolinska institutet
(författare)
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Karolinska InstitutetKarolinska institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Neurochemistry: Wiley127:2, s. 209-2200022-30421471-4159
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