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Long-Term Effects o...
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Jernberg, TomasKarolinska Institutet
(författare)
Long-Term Effects of Oxygen Therapy on Death or Hospitalization for Heart Failure in Patients With Suspected Acute Myocardial Infarction
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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LIPPINCOTT WILLIAMS & WILKINS,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-154871
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154871URI
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https://doi.org/10.1161/CIRCULATIONAHA.118.036220DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372939URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153672URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139760112URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Swedish Research Council [VR20130307]; Swedish Heart-Lung Foundation [HLF20130262, HLF20160688, HLF20170277]; Swedish Foundation for Strategic Research [SFF KF10-0024]
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Background: In the DETO2X-AMI trial (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air in normoxemic patients presenting with suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report the prespecified secondary end points cardiovascular death and the composite of all-cause death and hospitalization for heart failure.Methods: In this pragmatic, registry-based randomized clinical trial, we used a nationwide quality registry for coronary care for trial procedures and evaluated end points through the Swedish population registry (mortality), the Swedish inpatient registry (heart failure), and cause of death registry (cardiovascular death). Patients with suspected acute myocardial infarction and oxygen saturation of ≥90% were randomly assigned to receive either supplemental oxygen at 6 L/min for 6 to 12 hours delivered by open face mask or ambient air.Results: A total of 6629 patients were enrolled. Acute heart failure treatment, left ventricular systolic function assessed by echocardiography, and infarct size measured by high-sensitive cardiac troponin T were similar in the 2 groups during the hospitalization period. All-cause death or hospitalization for heart failure within 1 year after randomization occurred in 8.0% of patients assigned to oxygen and in 7.9% of patients assigned to ambient air (hazard ratio, 0.99; 95% CI, 0.84–1.18; P=0.92). During long-term follow-up (median [range], 2.1 [1.0–3.7] years), the composite end point occurred in 11.2% of patients assigned to oxygen and in 10.8% of patients assigned to ambient air (hazard ratio, 1.02; 95% CI, 0.88–1.17; P=0.84), and cardiovascular death occurred in 5.2% of patients assigned to oxygen and in 4.8% assigned to ambient air (hazard ratio, 1.07; 95% CI, 0.87–1.33; P=0.52). The results were consistent across all predefined subgroups.Conclusions: Routine use of supplemental oxygen in normoxemic patients with suspected myocardial infarction was not found to reduce the composite of all-cause mortality and hospitalization for heart failure, or cardiovascular death within 1 year or during long-term follow-up.Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01787110.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lindahl, Bertil,1957-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden(Swepub:uu)belin227
(författare)
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Alfredsson, JoakimLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)joaal38
(författare)
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Berglund, EllinorKarolinska Institutet
(författare)
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Bergström, OlleVaxjo Hosp, Dept Med, Vaxjo, Sweden
(författare)
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Engström, AndersKalmar Reg Hosp, Div Cardiol, Dept Med, Kalmar, Sweden
(författare)
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Erlinge, DavidLund Univ, Dept Clin Sci, Cardiol, Lund, Sweden
(författare)
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Herlitz, JohanUniv Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Cardiol, Gothenburg, Sweden;Univ Boras, Dept Hlth Sci, Boras, Sweden
(författare)
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Jumatate, RalucaKristianstad Hosp, Dept Med, Kristianstad, Sweden
(författare)
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Kellerth, ThomasOrebro Univ Hosp, Dept Cardiol, Orebro, Sweden
(författare)
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Lauermann, JörgRyhov Hosp, Div Cardiol, Dept Internal Med, Jonkoping, Sweden
(författare)
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Lindmark, KristerUmeå universitet,Kardiologi,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden(Swepub:umu)krli0021
(författare)
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Lingman, MarkusHalland Hosp, Dept Med, Halmstad, Sweden;Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden
(författare)
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Ljung, LinaKarolinska Institutet
(författare)
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Nilsson, CarinaLjungby Hosp, Dept Med, Ljungby, Sweden
(författare)
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Omerovic, ElmirUniv Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Cardiol, Gothenburg, Sweden
(författare)
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Pernow, JohnKarolinska Institutet
(författare)
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Ravn-Fischer, AnnicaUniv Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Cardiol, Gothenburg, Sweden
(författare)
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Sparv, DavidLund Univ, Dept Clin Sci, Cardiol, Lund, Sweden
(författare)
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Yndigegn, TroelsLund Univ, Dept Clin Sci, Cardiol, Lund, Sweden
(författare)
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Östlund, OllieUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden(Swepub:uu)oos27600
(författare)
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James, Stefan K,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden(Swepub:uu)stjam367
(författare)
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Hofmann, RobinKarolinska Institutet
(författare)
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Karolinska InstitutetKardiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Circulation: LIPPINCOTT WILLIAMS & WILKINS138:24, s. 2754-27620009-73221524-4539
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Jernberg, Tomas
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Lindahl, Bertil, ...
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Alfredsson, Joak ...
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Berglund, Ellino ...
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Bergström, Olle
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Engström, Anders
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Erlinge, David
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Herlitz, Johan
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Jumatate, Raluca
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Kellerth, Thomas
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Lauermann, Jörg
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Lindmark, Kriste ...
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Lingman, Markus
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Ljung, Lina
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Nilsson, Carina
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Omerovic, Elmir
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Pernow, John
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Ravn-Fischer, An ...
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Sparv, David
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Yndigegn, Troels
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Östlund, Ollie
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James, Stefan K, ...
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Hofmann, Robin
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