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High Plasma Oxytoci...
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Jokinen, JussiUmeå universitet,Institutionen för klinisk vetenskap
(författare)
High Plasma Oxytocin Levels in Men With Hypersexual Disorder
- Artikel/kapitelEngelska2019
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Nature Publishing Group,2019
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LIBRIS-ID:oai:DiVA.org:umu-168967
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168967URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Supplement: 1Meeting Abstract: M71
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Background: Hypersexual disorder (HD) integrating pathophysiological aspects such as sexual desire deregulation, sexual addiction, impulsivity and compulsivity was suggested as a diagnosis for the DSM-5. "Compulsive Sexual Behavior Disorder" is now presented as an impulse-control disorder in ICD-11. Recent studies showed dysregulated HPA axis in men with HD. Oxytocin (OXT) affects the function of the HPA axis; no studies have assessed OXT levels in patients with HD. Whether a CBT treatment for HD symptoms has an effect on OXT levels has not been investigated.Methods: We examined plasma OXT levels in 64 male patients with HD and 38 male age-matched healthy volunteers. Further, we examined correlations between plasma OXT levels and dimensional symptoms of HD using the rating scales measuring hypersexual behaviour: Hypersexual disorder screening inventory (HDSI) and the Sexual Compulsive scale (SCS). A part of the patients (N = 30) completed the manual-based group-administered CBT program for HD and had a secondary measurement of OXT at post-treatment. OXT was measured with Radioimmunoassay (RIA).Results: Patients with HD had significantly higher OXT (Mean 31.0 ± SD 9.9 pM) levels compared to healthy volunteers (Mean 16.9 ± SD 3.9 pM) (p < 0.001). There were significant positive correlations between OXT levels and the rating scales measuring hypersexual behaviour (Spearman rhos between HDSI r = 0.649, p < 0.001 and SCS r = 0.629, p < 0.001) in the study participants combined. Patients who completed CBT treatment had significant reduction of OXT levels from pre-treatment (30.5 ± 10.1pM) to post-treatment (20.2 ± 8.0pM) (p < 0.001). Patients with HD had a significant positive correlation of their changes in HD:CAS with plasma oxytocin level before and after CBT(r = 0.388, p value= 0.0344).Conclusions: The results suggest hyperactive oxytonergic system in male patients with hypersexual disorder which may be a compensatory mechanism to attenuate hyperactive stress system. A successful CBT group therapy may have effect on hyperactive oxytonergic system.
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Flanagan, John
(författare)
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Chatzittofis, AndreasUmeå universitet,Institutionen för klinisk vetenskap(Swepub:umu)anch0141
(författare)
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Öberg, Katarina
(författare)
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Arver, Stefan
(författare)
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Umeå universitetInstitutionen för klinisk vetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuropsychopharmacology: Nature Publishing Group44, s. 114-1140893-133X1740-634X
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