The prognostic role of LRIG proteins in endometrial cancer

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Razumova, Z.Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden (author)

The prognostic role of LRIG proteins in endometrial cancer

Article/chapterEnglish2019

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BMJ Publishing Group Ltd,2019
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LIBRIS-ID:oai:DiVA.org:umu-170024
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170024URI
https://doi.org/10.1136/ijgc-2019-ESGO.666DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81339URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:143428049URI

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Language:English
Summary in:English

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Supplement: 4Meeting Abstract: EP609
Introduction/Background Endometrial cancer (EC) is the most common gynaecological malignancy in Sweden. The disease has several prognostic factors. Still, the high amount of EC develops into more aggressive forms of cancer, even though being first considered to be non-aggressive. The LRIG proteins are a family of three integral surface proteins that have a similar domain organisation. The current study evaluated the role of LRIG proteins as prognostic biomarkers in EC.Methodology The cohort included 75 women who underwent a hysterectomy and bilateral salpingo-oophorectomydue to EC at the Department of Women's and Children's Health, Karolinska University Hospital Solna between 2007 and 2012. The expression of LRIG1, LRIG2, and LRIG3 in paraffin biopsies was analysed by immunohistochemistry (IHC) with applying specific polyclonal antibodies. Evaluation of immunostainings was performed by two senior pathologists without knowledge of the disease outcome. The percentage of positive cells was divided in two groups with median percentage as cut off to have two groups of equal size included in the statistical analysis. Then the groups were assessedin connection with different tumour characteristics and clinical outcomes of EC.Results The majority of women in the cohort had >50% LRIG1-, LRIG2-, and LRIG3-positive cells. Among 6047 person-months of follow-up a total, of 14 incident cases of relapsed EC were identified. A statistically significant association between high LRIG3 expression and superior overall survival was observed in the cohort (IRR=2.559, 95 CI=1.054–6.210, p=0.038). LRIG1 and LRIG2 expression did not significantly correlate with survival.Conclusion Our results support the hypothesis that LRIG3 expression may have a prognostic role in women with EC. The significance of LRIG1 and LRIG2 expression remains to be clarified.

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Oda, H.Department of Medical Biosciences, Umeå University, Umeå, Sweden (author)
Govorov, I.Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden (author)
Lundin, E.Department of Medical Biosciences, Umeå University, Umeå, Sweden (author)
Östensson, E.Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden (author)
Lindquist, DavidUmeå universitet,Onkologi,Department of Radiation Sciences, Umeå University, Umeå, Sweden(Swepub:umu)dali0066 (author)
Mints, Miriam,1958-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)mms (author)
Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, SwedenDepartment of Medical Biosciences, Umeå University, Umeå, Sweden (creator_code:org_t)

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In:International Journal of Gynecological Cancer: BMJ Publishing Group Ltd29, s. A358-A3581048-891X1525-1438

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By the author/editor: Razumova, Z.; Oda, H.; Govorov, I.; Lundin, E.; Östensson, E.; Lindquist, David; show more...; Mints, Miriam, 1 ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: International Jo ...

By the university: Umeå University; Örebro University; Karolinska Institutet

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