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c-Met expression in...
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Isaksson-Mettävainio, MartinUmeå universitet,Patologi
(författare)
c-Met expression in primary tumors and their corresponding distant metastases
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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Umeå :Spandidos Publications,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-33121
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33121URI
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https://doi.org/10.3892/mmr_00000029DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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c-Met is a receptor tyrosine kinase that has beenimplicated in the pathogenesis and growth of a wide variety ofhuman malignancies, including CRC, but its role in metastasisis largely unknown. We compared c-Met expression in primaryhuman colorectal carcinomas and distant metastases from thesame patients. Formalin-fixed paraffin-embedded tissuesamples from 69 colorectal cancer patients were obtained. Theprotein expression of c-Met was evaluated immunohistochemicallyusing a commercial antibody. The difference inexpression between primary tumors and their correspondingdistant metastases was analyzed using the Wilcoxon signedranktest. c-Met expression was statistically significantlylower in the distant metastases compared to their correspondingprimary tumors (p<0.001), whereas no difference was foundbetween lymph node metastases and their correspondingprimary tumors (p=0.957). The degree of c-Met expressionwas not related to clinicopathological characteristics such astumor grade and Dukes' stage at the time of primary tumordiagnosis, or to the location of the distant metastases. Wedemonstrated that c-Met expression is often reduced in distantmetastases compared to their corresponding primary colorectaltumors. Additional studies of c-Met activation and signaltransduction will increase our knowledge about the role ofc-Met in colorectal cancer metastasis.
Ämnesord och genrebeteckningar
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c-Met
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colorectal cancer
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metastasis
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Van Guelpen, BethanyUmeå universitet,Patologi(Swepub:umu)beyvan99
(författare)
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Öberg, ÅkeUmeå universitet,Patologi
(författare)
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Stenling, RogerUmeå universitet,Patologi(Swepub:umu)rost0001
(författare)
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Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001
(författare)
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Henriksson, Maria LUmeå universitet,Patologi(Swepub:umu)mahe0061
(författare)
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Umeå universitetPatologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Medicine ReportsUmeå : Spandidos Publications1:6, s. 787-7901791-2997
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