SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-39054"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-39054" > Investigation of po...

  • Plant, Darren (författare)

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • 2010-05-24
  • BMJ,2010
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-39054
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39054URI
  • https://doi.org/10.1136/ard.2009.121020DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121042322URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background Genetic factors have a substantial role in determining development of rheumatoid arthritis (RA), and are likely to account for 50-60% of disease susceptibility. Genome-wide association studies have identified non-human leucocyte antigen RA susceptibility loci which associate with RA with low-to-moderate risk. Objectives To investigate recently identified RA susceptibility markers using cohorts from six European countries, and perform a meta-analysis including previously published results. Methods 3311 DNA samples were collected from patients from six countries (UK, Germany, France, Greece, Sweden and Denmark). Genotype data or DNA samples for 3709 controls were collected from four countries (not Sweden or Denmark). Eighteen single nucleotide polymorphisms (SNPs) were genotyped using Sequenom MassArray technology. Samples with a >95% success rate and only those SNPs with a genotype success rate of >95% were included in the analysis. Scandinavian patient data were pooled and previously published Swedish control data were accessed as a comparison group. Meta-analysis was used to combine results from this study with all previously published data. Results After quality control, 3209 patients and 3692 controls were included in the study. Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis. All 18 markers were associated with RA when previously published studies were incorporated in the analysis. Data from this study increased the significance for association with RA and nine markers. Conclusions In a large European RA cohort further evidence for the association of 18 markers with RA development has been obtained.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Flynn, Edward (författare)
  • Mbarek, Hamdi (författare)
  • Dieude, Philippe (författare)
  • Cornelis, Francois (författare)
  • Ärlestig, LisbethUmeå universitet,Reumatologi(Swepub:umu)litarg99 (författare)
  • Dahlqvist, Solbritt RantapääUmeå universitet,Reumatologi(Swepub:umu)sora0001 (författare)
  • Goulielmos, George (författare)
  • Boumpas, Dimitrios T (författare)
  • Sidiropoulos, Prodromos (författare)
  • Johansen, Julia S (författare)
  • Ornbjerg, Lykke M (författare)
  • Hetland, Merete Lund (författare)
  • Klareskog, LarsKarolinska Institutet (författare)
  • Filer, Andrew (författare)
  • Buckley, Christopher D (författare)
  • Raza, Karim (författare)
  • Witte, Torsten (författare)
  • Schmidt, Reinhold E (författare)
  • Worthington, Jane (författare)
  • Umeå universitetReumatologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Annals of the Rheumatic Diseases: BMJ69:8, s. 1548-15530003-49671468-2060

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy