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Sökning: onr:"swepub:oai:DiVA.org:umu-47658" > Genetic variants in...

  • Lin, Daniel W.Department of Urology, University of Washington School of Medicine, Seattle, WA (författare)

Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • Philadelphia :American Association for Cancer Research,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-47658
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47658URI
  • https://doi.org/10.1158/1055-9965.EPI-11-0236DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123193008URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Prostate cancer is the second leading cause of cancer-related deaths in men, accounting for more than 30,000 deaths annually. The purpose of this study was to test whether variation in selected candidate genes in biological pathways of interest for prostate cancer progression could help distinguish patients at higher risk for fatal prostate cancer. Methods: In this hypothesis-driven study, we genotyped 937 single nucleotide polymorphisms (SNPs) in 156 candidate genes in a population-based cohort of 1,309 prostate cancer patients. We identified 22 top-ranking SNPs (P <= 0.01, FDR <= 0.70) associated with prostate cancer-specific mortality (PCSM). A subsequent validation study was completed in an independent population-based cohort of 2,875 prostate cancer patients. Results: Five SNPs were validated (P <= 0.05) as being significantly associated with PCSM, one each in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes. Compared with patients with 0 to 2 of the at-risk genotypes those with 4 to 5 at-risk genotypes had a 50% (95% CI, 1.2-1.9) higher risk of PCSM and risk increased with the number of at-risk genotypes carried (P(trend) = 0.001), adjusting for clinicopathologic factors known to influence prognosis. Conclusion: Five genetic markers were validated to be associated with lethal prostate cancer. Impact: This is the first population-based study to show that germline genetic variants provide prognostic information for prostate cancer-specific survival. The clinical utility of this five-SNP panel to stratify patients at higher risk for adverse outcomes should be evaluated. Cancer Epidemiol Biomarkers Prev; 20(9); 1928-36. (C)2011 AACR.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • FitzGerald, Liesel M.Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (författare)
  • Fu, RongDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Biostatistics, University of Washington, Seattle, WA (författare)
  • Kwon, Erika M.Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD (författare)
  • Zheng, Siqun LillyCenter for Cancer Genomics and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC (författare)
  • Kolb, SuzanneDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (författare)
  • Wiklund, FredrikKarolinska Institutet (författare)
  • Stattin, PaerUmeå universitet,Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)past0003 (författare)
  • Isaacs, William B.Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland (författare)
  • Xu, JianfengCenter for Cancer Genomics and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC (författare)
  • Ostrander, Elaine A.Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD (författare)
  • Feng, ZidingDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Biostatistics, University of Washington, Seattle, WA (författare)
  • Grönberg, HenrikKarolinska Institutet (författare)
  • Stanford, Janet L.Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington (författare)
  • Department of Urology, University of Washington School of Medicine, Seattle, WADivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Epidemiology, Biomarkers and PreventionPhiladelphia : American Association for Cancer Research20:9, s. 1928-19361055-99651538-7755

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