SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-83882"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-83882" > Allergies, atopy, i...

  • Lupo, Philip J. (författare)

Allergies, atopy, immune-related factors and childhood rhabdomyosarcoma : a report from the Children's Oncology Group

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • 2013-08-01
  • Wiley-Blackwell,2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-83882
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-83882URI
  • https://doi.org/10.1002/ijc.28363DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Rhabdomyosarcoma (RMS) is a highly malignant tumor of developing muscle that can occur anywhere in the body. Due to its rarity, relatively little is known about the epidemiology of RMS. Atopic disease is hypothesized to be protective against several malignancies; however, to our knowledge, there have been no assessments of atopy and childhood RMS. Therefore, we explored this association in a case-control study of 322 childhood RMS cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Controls were matched to cases on race, sex and age. The following atopic conditions were assessed: allergies, asthma, eczema and hives; in addition, we examined other immune-related factors: birth order, day-care attendance and breastfeeding. Conditional logistic-regression models were used to calculate an odds ratio (OR) and 95% confidence interval (CI) for each exposure, adjusted for age, race, sex, household income and parental education. As the two most common histologic types of RMS are embryonal (n=215) and alveolar (n=66), we evaluated effect heterogeneity of these exposures. Allergies (OR=0.60, 95% CI: 0.41-0.87), hives (OR=0.61, 95% CI: 0.38-0.97), day-care attendance (OR=0.48, 95% CI: 0.32-0.71) and breastfeeding for12 months (OR=0.36, 95% CI: 0.18-0.70) were inversely associated with childhood RMS. These exposures did not display significant effect heterogeneity between histologic types (p>0.52 for all exposures). This is the first study indicating that atopic exposures may be protective against childhood RMS, suggesting additional studies are needed to evaluate the immune system's role in the development of this tumor.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zhou, Renke (författare)
  • Skapek, Stephen X. (författare)
  • Hawkins, Douglas S. (författare)
  • Spector, Logan G. (författare)
  • Scheurer, Michael E. (författare)
  • Okcu, M. Fatih (författare)
  • Melin, BeatriceUmeå universitet,Onkologi(Swepub:umu)bema0010 (författare)
  • Papworth, KarinUmeå universitet,Onkologi(Swepub:umu)kanpah98 (författare)
  • Erhardt, Erik B. (författare)
  • Grufferman, Seymour (författare)
  • Umeå universitetOnkologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Cancer: Wiley-Blackwell134:2, s. 431-4360020-71361097-0215

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy