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Maternal and birth ...
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Lupo, Philip J.
(författare)
Maternal and birth characteristics and childhood rhabdomyosarcoma : a report from the Children's Oncology Group
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-05-16
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Springer Science and Business Media LLC,2014
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-91050
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-91050URI
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https://doi.org/10.1007/s10552-014-0390-6DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Previous assessments of childhood rhabdomyosarcoma have indicated maternal and birth characteristics may be associated with tumor development; however, much work remains to identify novel and confirm suspected risk factors. Our objective was to evaluate the associations between maternal and birth characteristics and childhood rhabdomyosarcoma. This case-control study included 322 cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Population-based controls were identified using random digit dialing and were individually matched to cases on race, sex, and age. Families of the case and control subjects participated in a telephone interview, which captured information on maternal characteristics (birth control use, number of prenatal visits, anemia, and abnormal bleeding during pregnancy) and birth characteristics [birth weight, preterm birth, and type of delivery (vaginal vs. cesarean)]. Conditional logistic regression models were used to calculate an odds ratio (OR) and 95 % confidence interval (CI) for each exposure, adjusted for age, race, sex, household income, and parental education. As the two most common histologic types of rhabdomyosarcoma are embryonal (n = 215) and alveolar (n = 66), we evaluated effect heterogeneity of these exposures. The only characteristic that was associated with childhood rhabdomyosarcoma, and statistically significant, was abnormal vaginal bleeding during pregnancy (OR 1.75, 95 % CI 1.12-2.74). Birth control use (OR 1.45, 95 % CI 0.96-2.18), anemia during pregnancy (OR 1.27, 95 % CI 0.81-1.99), and preterm birth (OR 2.51, 95 % CI 0.74-8.49) were positively associated with childhood rhabdomyosarcoma, but were not statistically significant. Low birth weight [adjusted odds ratios (aOR) 4.46, 95 % CI 1.41-14.1] and high birth weight (aOR 2.41, 95 % CI 1.09-5.35) were strongly associated with alveolar rhabdomyosarcoma. However, these factors did not display significant effect heterogeneity between histologic types (p > 0.15 for all characteristics). Overall, we found little evidence that these maternal and birth characteristics are strongly associated with childhood rhabdomyosarcoma.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Danysh, Heather E.
(författare)
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Skapek, Stephen X.
(författare)
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Hawkins, Douglas S.
(författare)
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Spector, Logan G.
(författare)
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Zhou, Renke
(författare)
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Okcu, M. Fatih
(författare)
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Papworth, KarinUmeå universitet,Onkologi(Swepub:umu)kanpah98
(författare)
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Erhardt, Erik B.
(författare)
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Grufferman, Seymour
(författare)
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Umeå universitetOnkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancer Causes and Control: Springer Science and Business Media LLC25:7, s. 905-9130957-52431573-7225
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Lupo, Philip J.
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Danysh, Heather ...
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Skapek, Stephen ...
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Hawkins, Douglas ...
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Spector, Logan G ...
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Zhou, Renke
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Okcu, M. Fatih
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Papworth, Karin
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Erhardt, Erik B.
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