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Renin-angiotensin s...
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Bang, Casper N.
(författare)
Renin-angiotensin system inhibition is not associated with increased sudden cardiac death, cardiovascular mortality or all-cause mortality in patients with aortic stenosis
- Artikel/kapitelEngelska2014
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Elsevier BV,2014
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LIBRIS-ID:oai:DiVA.org:umu-93221
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-93221URI
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https://doi.org/10.1016/j.ijcard.2014.06.013DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background: Renin-angiotensin system inhibition (RASI) is frequently avoided in aortic stenosis (AS) patients because of fear of hypotension. We evaluated if RASI with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) increased mortality in patients with mild to moderate AS. Methods: All patients (n = 1873) from the Simvastatin and Ezetimibe in Aortic Stenosis study: asymptomatic patients with AS and preserved left ventricular (LV) ejection fraction were included. Risks of sudden cardiac death (SCD), cardiovascular death and all-cause mortality according to RASI treatment were analyzed by multivariable time-varying Cox models and propensity score matched analyses. Results: 769 (41%) patients received RASI. During a median follow-up of 4.3 +/- 0.9 years, 678 patients were categorized as having severe AS, 545 underwent aortic valve replacement, 40 SCDs, 103 cardiovascular and 205 all-cause deaths occurred. RASI was not associated with SCD (HR: 1.19 [95% CI: 0.50-2.83], p = 0.694), cardiovascular (HR: 1.05 [95% CI: 0.62-1.77], p = 0.854) or all-cause mortality (HR: 0.81 [95% CI: 0.55-1.20], p = 0.281). This was confirmed in propensity matched analysis (all p > 0.05). In separate analyses, RASI was associated with larger reduction in systolic blood pressure (p = 0.001) and less progression of LV mass (p = 0.040). Conclusions: RASI was not associated with SCD, cardiovascular or all-cause mortality in asymptomatic AS patients. However, RASI was associated with a potentially beneficial decrease in blood pressure and reduced LV mass progression. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Greve, Anders M.
(författare)
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Kober, Lars
(författare)
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Rossebo, Anne B.
(författare)
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Ray, Simon
(författare)
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Boman, KurtUmeå universitet,Medicin,Skellefteå Research Unit(Swepub:umu)kubo0001
(författare)
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Nienaber, Christoph A.
(författare)
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Devereux, Richard B.
(författare)
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Wachtell, Kristian
(författare)
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Umeå universitetMedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Cardiology: Elsevier BV175:3, s. 492-4980167-52731874-1754
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