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The CALHM1 P86L Pol...
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Lambert, Jean-Charles
(author)
The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease : a Meta-Analysis Study
- Article/chapterEnglish2010
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-133613
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-133613URI
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https://doi.org/10.3233/JAD-2010-100933DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon 4 allele of the APOE gene.
Subject headings and genre
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Age at onset
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Alzheimer's disease
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apolipoprotein E
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CALHM1
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polymorphism
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Sleegers, Kristel
(author)
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Gonzalez-Perez, Antonio
(author)
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Ingelsson, MartinUppsala universitet,Geriatrik,Molekylär geriatrik(Swepub:uu)maing121
(author)
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Beecham, Gary W.
(author)
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Hiltunen, Mikko
(author)
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Combarros, Onofre
(author)
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Bullido, Maria J.
(author)
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Brouwers, Nathalie
(author)
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Bettens, Karolien
(author)
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Berr, Claudine
(author)
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Pasquier, Florence
(author)
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Richard, Florence
(author)
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DeKosky, Steven T.
(author)
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Hannequin, Didier
(author)
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Haines, Jonathan L.
(author)
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Tognoni, Gloria
(author)
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Fievet, Nathalie
(author)
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Dartigues, Jean-Francois
(author)
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Tzourio, Christophe
(author)
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Engelborghs, Sebastiaan
(author)
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Arosio, Beatrice
(author)
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Coto, Elicer
(author)
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De Deyn, Peter
(author)
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Del Zompo, Maria
(author)
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Mateo, Ignacio
(author)
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Boada, Merce
(author)
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Antunez, Carmen
(author)
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Lopez-Arrieta, Jesus
(author)
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Epelbaum, Jacques
(author)
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Schjcide, Brit-Marcn Michaud
(author)
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Frank-Garcia, Ana
(author)
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Giedraitis, VilmantasUppsala universitet,Geriatrik,Molekylär geriatrik(Swepub:uu)vigie517
(author)
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Helisalmi, Seppo
(author)
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Porcellini, Elisa
(author)
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Pilotto, Alberto
(author)
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Forti, Paola
(author)
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Ferri, Raffaele
(author)
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Delepine, Marc
(author)
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Zelenika, Diana
(author)
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Lathrop, Mark
(author)
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Scarpini, Elio
(author)
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Siciliano, Gabriele
(author)
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Solfrizzi, Vincenzo
(author)
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Sorbi, Sandro
(author)
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Spalletta, Gianfranco
(author)
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Ravaglia, Giovanni
(author)
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Valdivieso, Fernando
(author)
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Vepsäläinen, SailaUniversity of Eastern Finland, Institute of Clinical Medicine / Neurology
(author)
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Alvarez, Victoria
(author)
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Bosco, Paolo
(author)
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Mancuso, Michelangelo
(author)
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Panza, Francesco
(author)
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Nacmias, Benedetta
(author)
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Bossu, Paola
(author)
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Hanon, Olivier
(author)
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Piccardi, Paola
(author)
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Annoni, Giorgio
(author)
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Mann, David
(author)
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Marambaud, Philippe
(author)
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Seripa, Davide
(author)
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Galimberti, Daniela
(author)
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Tanzi, Rudolph E.
(author)
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Bertram, Lars
(author)
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Lendon, Corinne
(author)
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Lannfelt, LarsUppsala universitet,Geriatrik,Molekylär geriatrik(Swepub:uu)lalan021
(author)
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Licastro, Federico
(author)
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Campion, Dominique
(author)
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Pericak-Vance, Margaret A.
(author)
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Soininen, Hilkka
(author)
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Van Broeckhoven, Christine
(author)
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Alperovitch, Annick
(author)
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Ruiz, Agustin
(author)
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Kamboh, M. Ilyas
(author)
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Amouyel, Philippe
(author)
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Uppsala universitetGeriatrik
(creator_code:org_t)
Related titles
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In:Journal of Alzheimer's Disease22:1, s. 247-2551387-28771875-8908
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Lambert, Jean-Ch ...
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Sleegers, Kriste ...
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Gonzalez-Perez, ...
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Ingelsson, Marti ...
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Beecham, Gary W.
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Hiltunen, Mikko
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Combarros, Onofr ...
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Bullido, Maria J ...
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Brouwers, Nathal ...
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Bettens, Karolie ...
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Berr, Claudine
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Pasquier, Floren ...
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Richard, Florenc ...
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DeKosky, Steven ...
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Hannequin, Didie ...
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Haines, Jonathan ...
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Fievet, Nathalie
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Dartigues, Jean- ...
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Tzourio, Christo ...
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Engelborghs, Seb ...
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Arosio, Beatrice
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Coto, Elicer
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De Deyn, Peter
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Del Zompo, Maria
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Mateo, Ignacio
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Boada, Merce
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Antunez, Carmen
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Lopez-Arrieta, J ...
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Epelbaum, Jacque ...
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Schjcide, Brit-M ...
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Giedraitis, Vilm ...
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Helisalmi, Seppo
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Porcellini, Elis ...
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Pilotto, Alberto
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Forti, Paola
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Ferri, Raffaele
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Zelenika, Diana
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Lathrop, Mark
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Scarpini, Elio
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Siciliano, Gabri ...
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Solfrizzi, Vince ...
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Sorbi, Sandro
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Vepsäläinen, Sai ...
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Alvarez, Victori ...
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Mancuso, Michela ...
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Nacmias, Benedet ...
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Bossu, Paola
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Hanon, Olivier
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Piccardi, Paola
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Annoni, Giorgio
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Mann, David
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Marambaud, Phili ...
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Seripa, Davide
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Galimberti, Dani ...
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Tanzi, Rudolph E ...
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Bertram, Lars
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Lendon, Corinne
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Lannfelt, Lars
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Licastro, Federi ...
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Campion, Dominiq ...
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Pericak-Vance, M ...
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Soininen, Hilkka
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Van Broeckhoven, ...
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Alperovitch, Ann ...
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Ruiz, Agustin
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Kamboh, M. Ilyas
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Amouyel, Philipp ...
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Uppsala University