Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: onr:"swepub:oai:DiVA.org:uu-134252" > Meta-analysis ident...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Heid, Iris M (author)

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-10-10
Springer Science and Business Media LLC,2010
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-134252
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134252URI
https://doi.org/10.1038/ng.685DOI
https://gup.ub.gu.se/publication/127954URI
https://lup.lub.lu.se/record/1719319URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:121530057URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Group Author(s): MAGIC
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Jackson, Anne U (author)
Randall, Joshua C (author)
Winkler, Thomas W (author)
Qi, Lu (author)
Steinthorsdottir, Valgerdur (author)
Thorleifsson, Gudmar (author)
Zillikens, M Carola (author)
Speliotes, Elizabeth K (author)
Mägi, Reedik (author)
Workalemahu, Tsegaselassie (author)
White, Charles C (author)
Bouatia-Naji, Nabila (author)
Harris, Tamara B (author)
Berndt, Sonja I (author)
Ingelsson, ErikKarolinska Institutet (author)
Willer, Cristen J (author)
Weedon, Michael N (author)
Luan, Jian'an (author)
Vedantam, Sailaja (author)
Esko, Tõnu (author)
Kilpeläinen, Tuomas O (author)
Kutalik, Zoltán (author)
Li, Shengxu (author)
Monda, Keri L (author)
Dixon, Anna L (author)
Holmes, Christopher C (author)
Kaplan, Lee M (author)
Liang, Liming (author)
Min, Josine L (author)
Moffatt, Miriam F (author)
Molony, Cliona (author)
Nicholson, George (author)
Schadt, Eric E (author)
Zondervan, Krina T (author)
Feitosa, Mary F (author)
Ferreira, Teresa (author)
Allen, Hana Lango (author)
Weyant, Robert J (author)
Wheeler, Eleanor (author)
Wood, Andrew R (author)
Estrada, Karol (author)
Goddard, Michael E (author)
Lettre, Guillaume (author)
Mangino, Massimo (author)
Nyholt, Dale R (author)
Purcell, Shaun (author)
Smith, Albert Vernon (author)
Visscher, Peter M (author)
Yang, Jian (author)
McCarroll, Steven A (author)
Nemesh, James (author)
Voight, Benjamin F (author)
Absher, Devin (author)
Amin, Najaf (author)
Aspelund, Thor (author)
Coin, Lachlan (author)
Glazer, Nicole L (author)
Hayward, Caroline (author)
Heard-Costa, Nancy L (author)
Hottenga, Jouke-Jan (author)
Johansson, ÅsaUppsala universitet,Genomik,Gyllensten(Swepub:uu)asjoh108 (author)
Johnson, Toby (author)
Kaakinen, Marika (author)
Kapur, Karen (author)
Ketkar, Shamika (author)
Knowles, Joshua W (author)
Kraft, Peter (author)
Kraja, Aldi T (author)
Lamina, Claudia (author)
Leitzmann, Michael F (author)
McKnight, Barbara (author)
Morris, Andrew P (author)
Ong, Ken K (author)
Perry, John R B (author)
Peters, Marjolein J (author)
Polasek, Ozren (author)
Prokopenko, Inga (author)
Rayner, Nigel W (author)
Ripatti, Samuli (author)
Rivadeneira, Fernando (author)
Robertson, Neil R (author)
Sanna, Serena (author)
Sovio, Ulla (author)
Surakka, Ida (author)
Teumer, Alexander (author)
van Wingerden, Sophie (author)
Vitart, Veronique (author)
Zhao, Jing Hua (author)
Cavalcanti-Proença, Christine (author)
Chines, Peter S (author)
Fisher, Eva (author)
Kulzer, Jennifer R (author)
Lecoeur, Cecile (author)
Narisu, Narisu (author)
Sandholt, Camilla (author)
Scott, Laura J (author)
Silander, Kaisa (author)
Stark, Klaus (author)
Tammesoo, Mari-Liis (author)
Teslovich, Tanya M (author)
Timpson, Nicholas John (author)
Watanabe, Richard M (author)
Welch, Ryan (author)
Chasman, Daniel I (author)
Cooper, Matthew N (author)
Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xjanjo (author)
Kettunen, Johannes (author)
Lawrence, Robert W (author)
Pellikka, Niina (author)
Perola, Markus (author)
Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xvanli (author)
Alavere, Helene (author)
Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal (author)
Atwood, Larry D (author)
Bennett, Amanda J (author)
Biffar, Reiner (author)
Bonnycastle, Lori L (author)
Bornstein, Stefan R (author)
Buchanan, Thomas A (author)
Campbell, Harry (author)
Day, Ian N M (author)
Dei, Mariano (author)
Dörr, Marcus (author)
Elliott, Paul (author)
Erdos, Michael R (author)
Eriksson, Johan G (author)
Freimer, Nelson B (author)
Fu, Mao (author)
Gaget, Stefan (author)
Geus, Eco J C (author)
Gjesing, Anette P (author)
Grallert, Harald (author)
Grässler, Jürgen (author)
Groves, Christopher J (author)
Guiducci, Candace (author)
Hartikainen, Anna-Liisa (author)
Hassanali, Neelam (author)
Havulinna, Aki S (author)
Herzig, Karl-Heinz (author)
Hicks, Andrew A (author)
Hui, Jennie (author)
Igl, WilmarUppsala universitet,Institutionen för genetik och patologi (author)
Jousilahti, Pekka (author)
Jula, Antti (author)
Kajantie, Eero (author)
Kinnunen, Leena (author)
Kolcic, Ivana (author)
Koskinen, Seppo (author)
Kovacs, Peter (author)
Kroemer, Heyo K (author)
Krzelj, Vjekoslav (author)
Kuusisto, Johanna (author)
Kvaloy, Kirsti (author)
Laitinen, Jaana (author)
Lantieri, Olivier (author)
Lathrop, G Mark (author)
Lokki, Marja-Liisa (author)
Luben, Robert N (author)
Ludwig, Barbara (author)
McArdle, Wendy L (author)
McCarthy, Anne (author)
Morken, Mario A (author)
Nelis, Mari (author)
Neville, Matt J (author)
Paré, Guillaume (author)
Parker, Alex N (author)
Peden, John F (author)
Pichler, Irene (author)
Pietiläinen, Kirsi H (author)
Platou, Carl G P (author)
Pouta, Anneli (author)
Ridderstråle, MartinLund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups(Swepub:lu)endo-mri (author)
Samani, Nilesh J (author)
Saramies, Jouko (author)
Sinisalo, Juha (author)
Smit, Jan H (author)
Strawbridge, Rona JKarolinska Institutet (author)
Stringham, Heather M (author)
Swift, Amy J (author)
Teder-Laving, Maris (author)
Thomson, Brian (author)
Usala, Gianluca (author)
van Meurs, Joyce B J (author)
van Ommen, Gert-Jan (author)
Vatin, Vincent (author)
Volpato, Claudia B (author)
Wallaschofski, Henri (author)
Walters, G Bragi (author)
Widen, Elisabeth (author)
Wild, Sarah H (author)
Willemsen, Gonneke (author)
Witte, Daniel R (author)
Zgaga, Lina (author)
Zitting, Paavo (author)
Beilby, John P (author)
James, Alan L (author)
Kähönen, Mika (author)
Lehtimäki, Terho (author)
Nieminen, Markku S (author)
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xohlcl (author)
Palmer, Lyle J (author)
Raitakari, Olli (author)
Ridker, Paul M (author)
Stumvoll, Michael (author)
Tönjes, Anke (author)
Viikari, Jorma (author)
Balkau, Beverley (author)
Ben-Shlomo, Yoav (author)
Bergman, Richard N (author)
Boeing, Heiner (author)
Smith, George Davey (author)
Ebrahim, Shah (author)
Froguel, Philippe (author)
Hansen, Torben (author)
Hengstenberg, Christian (author)
Hveem, Kristian (author)
Isomaa, Bo (author)
Jørgensen, Torben (author)
Karpe, Fredrik (author)
Khaw, Kay-Tee (author)
Laakso, Markku (author)
Lawlor, Debbie A (author)
Marre, Michel (author)
Meitinger, Thomas (author)
Metspalu, Andres (author)
Midthjell, Kristian (author)
Pedersen, Oluf (author)
Salomaa, Veikko (author)
Schwarz, Peter E H (author)
Tuomi, Tiinamaija (author)
Tuomilehto, Jaakko (author)
Valle, Timo T (author)
Wareham, Nicholas J (author)
Arnold, Alice M (author)
Beckmann, Jacques S (author)
Bergmann, Sven (author)
Boerwinkle, Eric (author)
Boomsma, Dorret I (author)
Caulfield, Mark J (author)
Collins, Francis S (author)
Eiriksdottir, Gudny (author)
Gudnason, Vilmundur (author)
Gyllensten, UlfUppsala universitet,Institutionen för genetik och patologi,Gyllensten(Swepub:uu)ulfgyll (author)
Hamsten, AndersKarolinska Institutet (author)
Hattersley, Andrew T (author)
Hofman, Albert (author)
Hu, Frank B (author)
Illig, Thomas (author)
Iribarren, Carlos (author)
Jarvelin, Marjo-Riitta (author)
Kao, W H Linda (author)
Kaprio, Jaakko (author)
Launer, Lenore J (author)
Munroe, Patricia B (author)
Oostra, Ben (author)
Penninx, Brenda W (author)
Pramstaller, Peter P (author)
Psaty, Bruce M (author)
Quertermous, Thomas (author)
Rissanen, Aila (author)
Rudan, Igor (author)
Shuldiner, Alan R (author)
Soranzo, Nicole (author)
Spector, Timothy D (author)
Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva (author)
Uda, Manuela (author)
Uitterlinden, André (author)
Völzke, Henry (author)
Vollenweider, Peter (author)
Wilson, James F (author)
Witteman, Jacqueline C (author)
Wright, Alan F (author)
Abecasis, Gonçalo R (author)
Boehnke, Michael (author)
Borecki, Ingrid B (author)
Deloukas, Panos (author)
Frayling, Timothy M (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Haritunians, Talin (author)
Hunter, David J (author)
Kaplan, Robert C (author)
North, Kari E (author)
O'Connell, Jeffrey R (author)
Peltonen, Leena (author)
Schlessinger, David (author)
Strachan, David P (author)
Hirschhorn, Joel N (author)
Assimes, Themistocles L (author)
Wichmann, H-Erich (author)
Thorsteinsdottir, Unnur (author)
van Duijn, Cornelia M (author)
Stefansson, Kari (author)
Cupples, L Adrienne (author)
Loos, Ruth J F (author)
Barroso, Inês (author)
McCarthy, Mark I (author)
Fox, Caroline S (author)
Mohlke, Karen L (author)
Lindgren, Cecilia M (author)
Luan, Jianan (author)
Karolinska InstitutetGenomik (creator_code:org_t)

Related titles

In:Nature Genetics: Springer Science and Business Media LLC42:11, s. 949-9601061-40361546-1718

Internet link

Find in a library

Nature Genetics (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Heid, Iris M; Jackson, Anne U; Randall, Joshua ...; Winkler, Thomas ...; Qi, Lu; Steinthorsdottir ...; show more...; Thorleifsson, Gu ...; Zillikens, M Car ...; Speliotes, Eliza ...; Mägi, Reedik; Workalemahu, Tse ...; White, Charles C; Bouatia-Naji, Na ...; Harris, Tamara B; Berndt, Sonja I; Ingelsson, Erik; Willer, Cristen ...; Weedon, Michael ...; Luan, Jian'an; Vedantam, Sailaj ...; Esko, Tõnu; Kilpeläinen, Tuo ...; Kutalik, Zoltán; Li, Shengxu; Monda, Keri L; Dixon, Anna L; Holmes, Christop ...; Kaplan, Lee M; Liang, Liming; Min, Josine L; Moffatt, Miriam ...; Molony, Cliona; Nicholson, Georg ...; Schadt, Eric E; Zondervan, Krina ...; Feitosa, Mary F; Ferreira, Teresa; Allen, Hana Lang ...; Weyant, Robert J; Wheeler, Eleanor; Wood, Andrew R; Estrada, Karol; Goddard, Michael ...; Lettre, Guillaum ...; Mangino, Massimo; Nyholt, Dale R; Purcell, Shaun; Smith, Albert Ve ...; Visscher, Peter ...; Yang, Jian; McCarroll, Steve ...; Nemesh, James; Voight, Benjamin ...; Absher, Devin; Amin, Najaf; Aspelund, Thor; Coin, Lachlan; Glazer, Nicole L; Hayward, Carolin ...; Heard-Costa, Nan ...; Hottenga, Jouke- ...; Johansson, Åsa; Johnson, Toby; Kaakinen, Marika; Kapur, Karen; Ketkar, Shamika; Knowles, Joshua ...; Kraft, Peter; Kraja, Aldi T; Lamina, Claudia; Leitzmann, Micha ...; McKnight, Barbar ...; Morris, Andrew P; Ong, Ken K; Perry, John R B; Peters, Marjolei ...; Polasek, Ozren; Prokopenko, Inga; Rayner, Nigel W; Ripatti, Samuli; Rivadeneira, Fer ...; Robertson, Neil ...; Sanna, Serena; Sovio, Ulla; Surakka, Ida; Teumer, Alexande ...; van Wingerden, S ...; Vitart, Veroniqu ...; Zhao, Jing Hua; Cavalcanti-Proen ...; Chines, Peter S; Fisher, Eva; Kulzer, Jennifer ...; Lecoeur, Cecile; Narisu, Narisu; Sandholt, Camill ...; Scott, Laura J; Silander, Kaisa; Stark, Klaus; Tammesoo, Mari-L ...; Teslovich, Tanya ...; Timpson, Nichola ...; Watanabe, Richar ...; Welch, Ryan; Chasman, Daniel ...; Cooper, Matthew ...; Jansson, John-Ol ...; Kettunen, Johann ...; Lawrence, Robert ...; Pellikka, Niina; Perola, Markus; Vandenput, Liesb ...; Alavere, Helene; Almgren, Peter; Atwood, Larry D; Bennett, Amanda ...; Biffar, Reiner; Bonnycastle, Lor ...; Bornstein, Stefa ...; Buchanan, Thomas ...; Campbell, Harry; Day, Ian N M; Dei, Mariano; Dörr, Marcus; Elliott, Paul; Erdos, Michael R; Eriksson, Johan ...; Freimer, Nelson ...; Fu, Mao; Gaget, Stefan; Geus, Eco J C; Gjesing, Anette ...; Grallert, Harald; Grässler, Jürgen; Groves, Christop ...; Guiducci, Candac ...; Hartikainen, Ann ...; Hassanali, Neela ...; Havulinna, Aki S; Herzig, Karl-Hei ...; Hicks, Andrew A; Hui, Jennie; Igl, Wilmar; Jousilahti, Pekk ...; Jula, Antti; Kajantie, Eero; Kinnunen, Leena; Kolcic, Ivana; Koskinen, Seppo; Kovacs, Peter; Kroemer, Heyo K; Krzelj, Vjekosla ...; Kuusisto, Johann ...; Kvaloy, Kirsti; Laitinen, Jaana; Lantieri, Olivie ...; Lathrop, G Mark; Lokki, Marja-Lii ...; Luben, Robert N; Ludwig, Barbara; McArdle, Wendy L; McCarthy, Anne; Morken, Mario A; Nelis, Mari; Neville, Matt J; Paré, Guillaume; Parker, Alex N; Peden, John F; Pichler, Irene; Pietiläinen, Kir ...; Platou, Carl G P; Pouta, Anneli; Ridderstråle, Ma ...; Samani, Nilesh J; Saramies, Jouko; Sinisalo, Juha; Smit, Jan H; Strawbridge, Ron ...; Stringham, Heath ...; Swift, Amy J; Teder-Laving, Ma ...; Thomson, Brian; Usala, Gianluca; van Meurs, Joyce ...; van Ommen, Gert- ...; Vatin, Vincent; Volpato, Claudia ...; Wallaschofski, H ...; Walters, G Bragi; Widen, Elisabeth; Wild, Sarah H; Willemsen, Gonne ...; Witte, Daniel R; Zgaga, Lina; Zitting, Paavo; Beilby, John P; James, Alan L; Kähönen, Mika; Lehtimäki, Terho; Nieminen, Markku ...; Ohlsson, Claes, ...; Palmer, Lyle J; Raitakari, Olli; Ridker, Paul M; Stumvoll, Michae ...; Tönjes, Anke; Viikari, Jorma; Balkau, Beverley; Ben-Shlomo, Yoav; Bergman, Richard ...; Boeing, Heiner; Smith, George Da ...; Ebrahim, Shah; Froguel, Philipp ...; Hansen, Torben; Hengstenberg, Ch ...; Hveem, Kristian; Isomaa, Bo; Jørgensen, Torbe ...; Karpe, Fredrik; Khaw, Kay-Tee; Laakso, Markku; Lawlor, Debbie A; Marre, Michel; Meitinger, Thoma ...; Metspalu, Andres; Midthjell, Krist ...; Pedersen, Oluf; Salomaa, Veikko; Schwarz, Peter E ...; Tuomi, Tiinamaij ...; Tuomilehto, Jaak ...; Valle, Timo T; Wareham, Nichola ...; Arnold, Alice M; Beckmann, Jacque ...; Bergmann, Sven; Boerwinkle, Eric; Boomsma, Dorret ...; Caulfield, Mark ...; Collins, Francis ...; Eiriksdottir, Gu ...; Gudnason, Vilmun ...; Gyllensten, Ulf; Hamsten, Anders; Hattersley, Andr ...; Hofman, Albert; Hu, Frank B; Illig, Thomas; Iribarren, Carlo ...; Jarvelin, Marjo- ...; Kao, W H Linda; Kaprio, Jaakko; Launer, Lenore J; Munroe, Patricia ...; Oostra, Ben; Penninx, Brenda ...; Pramstaller, Pet ...; Psaty, Bruce M; Quertermous, Tho ...; Rissanen, Aila; Rudan, Igor; Shuldiner, Alan ...; Soranzo, Nicole; Spector, Timothy ...; Syvänen, Ann-Chr ...; Uda, Manuela; Uitterlinden, An ...; Völzke, Henry; Vollenweider, Pe ...; Wilson, James F; Witteman, Jacque ...; Wright, Alan F; Abecasis, Gonçal ...; Boehnke, Michael; Borecki, Ingrid ...; Deloukas, Panos; Frayling, Timoth ...; Groop, Leif; Haritunians, Tal ...; Hunter, David J; Kaplan, Robert C; North, Kari E; O'Connell, Jeffr ...; Peltonen, Leena; Schlessinger, Da ...; Strachan, David ...; Hirschhorn, Joel ...; Assimes, Themist ...; Wichmann, H-Eric ...; Thorsteinsdottir ...; van Duijn, Corne ...; Stefansson, Kari; Cupples, L Adrie ...; Loos, Ruth J F; Barroso, Inês; McCarthy, Mark I; Fox, Caroline S; Mohlke, Karen L; Lindgren, Cecili ...; Luan, Jianan; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Nature Genetics

By the university: Uppsala University; University of Gothenburg; Lund University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se