Discovery and refinement of loci associated with lipid levels

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Willer, Cristen J. (author)

Discovery and refinement of loci associated with lipid levels

Article/chapterEnglish2013

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2013-10-06
Springer Science and Business Media LLC,2013
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-211783
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211783URI
https://doi.org/10.1038/ng.2797DOI
https://lup.lub.lu.se/record/4204583URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127684100URI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-83626URI

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Language:English
Summary in:English

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De sex sista författarna delar sistaförfattarskapet.
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

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Schmidt, Ellen M. (author)
Sengupta, Sebanti (author)
Peloso, Gina M. (author)
Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732 (author)
Kanoni, Stavroula (author)
Ganna, AndreaKarolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab (author)
Chen, Jin (author)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Mora, Samia (author)
Beckmann, Jacques S. (author)
Bragg-Gresham, Jennifer L. (author)
Chang, Hsing-Yi (author)
Demirkan, Ayse (author)
Den Hertog, Heleen M. (author)
Do, Ron (author)
Donnelly, Louise A. (author)
Ehret, Georg B. (author)
Esko, Tonu (author)
Feitosa, Mary F. (author)
Ferreira, Teresa (author)
Fischer, Krista (author)
Fontanillas, Pierre (author)
Fraser, Ross M. (author)
Freitag, Daniel F. (author)
Gurdasani, Deepti (author)
Heikkila, Kauko (author)
Hyppoenen, Elina (author)
Isaacs, Aaron (author)
Jackson, Anne U. (author)
Johansson, ÅsaUppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)asjoh108 (author)
Johnson, Toby (author)
Kaakinen, Marika (author)
Kettunen, Johannes (author)
Kleber, Marcus E. (author)
Li, Xiaohui (author)
Luan, Jian'an (author)
Lyytikainen, Leo-Pekka (author)
Magnusson, Patrik K. E.Karolinska Institutet (author)
Mangino, Massimo (author)
Mihailov, Evelin (author)
Montasser, May E. (author)
Mueller-Nurasyid, Martina (author)
Nolte, Ilja M. (author)
O'Connell, Jeffrey R. (author)
Palmer, Cameron D. (author)
Perola, Markus (author)
Petersen, Ann-Kristin (author)
Sanna, Serena (author)
Saxena, Richa (author)
Service, Susan K. (author)
Shah, Sonia (author)
Shungin, DmitryUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi(Swepub:umu)dmsh0003 (author)
Sidore, Carlo (author)
Song, CiKarolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ciaso492 (author)
Strawbridge, Rona J.Karolinska Institutet (author)
Surakka, Ida (author)
Tanaka, Toshiko (author)
Teslovich, Tanya M. (author)
Thorleifsson, Gudmar (author)
Van den Herik, Evita G. (author)
Voight, Benjamin F. (author)
Volcik, Kelly A. (author)
Waite, Lindsay L. (author)
Wong, Andrew (author)
Wu, Ying (author)
Zhang, Weihua (author)
Absher, Devin (author)
Asiki, Gershim (author)
Barroso, Ines (author)
Been, Latonya F. (author)
Bolton, Jennifer L. (author)
Bonnycastle, Lori L. (author)
Brambilla, Paolo (author)
Burnett, Mary S. (author)
Cesana, Giancarlo (author)
Dimitriou, Maria (author)
Doney, Alex S. F. (author)
Doering, Angela (author)
Elliott, Paul (author)
Epstein, Stephen E. (author)
Eyjolfsson, Gudmundur Ingi (author)
Gigante, BrunaKarolinska Institutet (author)
Goodarzi, Mark O. (author)
Grallert, Harald (author)
Gravito, Martha L. (author)
Groves, Christopher J. (author)
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Hartikainen, Anna-Liisa (author)
Hayward, Caroline (author)
Hernandez, Dena (author)
Hicks, Andrew A. (author)
Holm, Hilma (author)
Hung, Yi-Jen (author)
Illig, Thomas (author)
Jones, Michelle R. (author)
Kaleebu, Pontiano (author)
Kastelein, John J. P. (author)
Khaw, Kay-Tee (author)
Kim, Eric (author)
Klopp, Norman (author)
Komulainen, Pirjo (author)
Kumari, Meena (author)
Langenberg, Claudia (author)
Lehtimaki, Terho (author)
Lin, Shih-Yi (author)
Lindstrom, Jaana (author)
Loos, Ruth J. F. (author)
Mach, Francois (author)
McArdle, Wendy L. (author)
Meisinger, Christa (author)
Mitchell, Braxton D. (author)
Mueller, Gabrielle (author)
Nagaraja, Ramaiah (author)
Narisu, NarisuKarolinska Institutet (author)
Nieminen, Tuomo V. M. (author)
Nsubuga, Rebecca N. (author)
Olafsson, Isleifur (author)
Ong, Ken K. (author)
Palotie, Aarno (author)
Papamarkou, Theodore (author)
Pomilla, Cristina (author)
Pouta, Anneli (author)
Rader, Daniel J. (author)
Reilly, Muredach P. (author)
Ridker, Paul M. (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Ruokonen, Aimo (author)
Samani, Nilesh (author)
Scharnagl, Hubert (author)
Seeley, Janet (author)
Silander, Kaisa (author)
Stancakova, Alena (author)
Stirrups, Kathleen (author)
Swift, Amy J. (author)
Tiret, Laurence (author)
Uitterlinden, Andre G. (author)
van Pelt, L. Joost (author)
Vedantam, Sailaja (author)
Wainwright, Nicholas (author)
Wijmenga, Cisca (author)
Wild, Sarah H. (author)
Willemsen, Gonneke (author)
Wilsgaard, Tom (author)
Wilson, James F. (author)
Young, Elizabeth H. (author)
Zhao, Jing Hua (author)
Adair, Linda S. (author)
Arveiler, Dominique (author)
Assimes, Themistocles L. (author)
Bandinelli, Stefania (author)
Bennett, Franklyn (author)
Bochud, Murielle (author)
Boehm, Bernhard O. (author)
Boomsma, Dorret I. (author)
Borecki, Ingrid B. (author)
Bornstein, Stefan R. (author)
Bovet, Pascal (author)
Burnier, Michel (author)
Campbell, Harry (author)
Chakravarti, Aravinda (author)
Chambers, John C. (author)
Chen, Yii-Der Ida (author)
Collins, Francis S. (author)
Cooper, Richard S. (author)
Danesh, John (author)
Dedoussis, George (author)
de Faire, UlfKarolinska Institutet (author)
Feranil, Alan B. (author)
Ferrieres, Jean (author)
Ferrucci, Luigi (author)
Freimer, Nelson B. (author)
Gieger, Christian (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Gudnason, Vilmundur (author)
Gyllensten, UlfUppsala universitet,Genomik(Swepub:uu)ulfgyll (author)
Hamsten, AndersKarolinska Institutet (author)
Harris, Tamara B. (author)
Hingorani, Aroon (author)
Hirschhorn, Joel N. (author)
Hofman, Albert (author)
Hovingh, G. Kees (author)
Hsiung, Chao Agnes (author)
Humphries, Steve E. (author)
Hunt, Steven C. (author)
Hveem, Kristian (author)
Iribarren, Carlos (author)
Jarvelin, Marjo-Riitta (author)
Jula, Antti (author)
Kahonen, Mika (author)
Kaprio, Jaakko (author)
Kesaniemi, Antero (author)
Kivimaki, Mika (author)
Kooner, Jaspal S. (author)
Koudstaal, Peter J. (author)
Krauss, Ronald M. (author)
Kuh, Diana (author)
Kuusisto, Johanna (author)
Kyvik, Kirsten O. (author)
Laakso, Markku (author)
Lakka, Timo A. (author)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Lindgren, Cecilia M. (author)
Martin, Nicholas G. (author)
Maerz, Winfried (author)
McCarthy, Mark I. (author)
McKenzie, Colin A. (author)
Meneton, Pierre (author)
Metspalu, Andres (author)
Moilanen, Leena (author)
Morris, Andrew D. (author)
Munroe, Patricia B. (author)
Njolstad, Inger (author)
Pedersen, Nancy L. (author)
Power, Chris (author)
Pramstaller, Peter P. (author)
Price, Jackie F. (author)
Psaty, Bruce M. (author)
Quertermous, Thomas (author)
Rauramaa, Rainer (author)
Saleheen, Danish (author)
Salomaa, Veikko (author)
Sanghera, Dharambir K. (author)
Saramies, Jouko (author)
Schwarz, Peter E. H. (author)
Sheu, Wayne H-H (author)
Shuldiner, Alan R. (author)
Siegbahn, AgnetaUppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Koagulation och inflammationsvetenskap(Swepub:uu)agsie424 (author)
Spector, Tim D. (author)
Stefansson, Kari (author)
Strachan, David P. (author)
Tayo, Bamidele O. (author)
Tremoli, Elena (author)
Tuomilehto, Jaakko (author)
Uusitupa, Matti (author)
van Duijn, Cornelia M. (author)
Vollenweider, Peter (author)
Wallentin, LarsUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)larswall (author)
Wareham, Nicholas J. (author)
Whitfield, John B. (author)
Wolffenbuttel, Bruce H. R. (author)
Ordovas, Jose M. (author)
Boerwinkle, Eric (author)
Palmer, Colin N. A. (author)
Thorsteinsdottir, Unnur (author)
Chasman, Daniel I. (author)
Rotter, Jerome I. (author)
Franks, PaulUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Lunds universitet, Harvard University(Swepub:umu)pafr0003 (author)
Ripatti, Samuli (author)
Cupples, L. Adrienne (author)
Sandhu, Manjinder S. (author)
Rich, Stephen S. (author)
Boehnke, Michael (author)
Deloukas, Panos (author)
Kathiresan, Sekar (author)
Mohlke, Karen L. (author)
Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425 (author)
Abecasis, Goncalo R. (author)
Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

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By the author/editor: Willer, Cristen ...; Schmidt, Ellen M ...; Sengupta, Sebant ...; Peloso, Gina M.; Gustafsson, Stef ...; Kanoni, Stavroul ...; show more...; Ganna, Andrea; Chen, Jin; Lind, Lars; Mora, Samia; Beckmann, Jacque ...; Bragg-Gresham, J ...; Chang, Hsing-Yi; Demirkan, Ayse; Den Hertog, Hele ...; Do, Ron; Donnelly, Louise ...; Ehret, Georg B.; Esko, Tonu; Feitosa, Mary F.; Ferreira, Teresa; Fischer, Krista; Fontanillas, Pie ...; Fraser, Ross M.; Freitag, Daniel ...; Gurdasani, Deept ...; Heikkila, Kauko; Hyppoenen, Elina; Isaacs, Aaron; Jackson, Anne U.; Johansson, Åsa; Johnson, Toby; Kaakinen, Marika; Kettunen, Johann ...; Kleber, Marcus E ...; Li, Xiaohui; Luan, Jian'an; Lyytikainen, Leo ...; Magnusson, Patri ...; Mangino, Massimo; Mihailov, Evelin; Montasser, May E ...; Mueller-Nurasyid ...; Nolte, Ilja M.; O'Connell, Jeffr ...; Palmer, Cameron ...; Perola, Markus; Petersen, Ann-Kr ...; Sanna, Serena; Saxena, Richa; Service, Susan K ...; Shah, Sonia; Shungin, Dmitry; Sidore, Carlo; Song, Ci; Strawbridge, Ron ...; Surakka, Ida; Tanaka, Toshiko; Teslovich, Tanya ...; Thorleifsson, Gu ...; Van den Herik, E ...; Voight, Benjamin ...; Volcik, Kelly A.; Waite, Lindsay L ...; Wong, Andrew; Wu, Ying; Zhang, Weihua; Absher, Devin; Asiki, Gershim; Barroso, Ines; Been, Latonya F.; Bolton, Jennifer ...; Bonnycastle, Lor ...; Brambilla, Paolo; Burnett, Mary S.; Cesana, Giancarl ...; Dimitriou, Maria; Doney, Alex S. F ...; Doering, Angela; Elliott, Paul; Epstein, Stephen ...; Eyjolfsson, Gudm ...; Gigante, Bruna; Goodarzi, Mark O ...; Grallert, Harald; Gravito, Martha ...; Groves, Christop ...; Hallmans, Göran; Hartikainen, Ann ...; Hayward, Carolin ...; Hernandez, Dena; Hicks, Andrew A.; Holm, Hilma; Hung, Yi-Jen; Illig, Thomas; Jones, Michelle ...; Kaleebu, Pontian ...; Kastelein, John ...; Khaw, Kay-Tee; Kim, Eric; Klopp, Norman; Komulainen, Pirj ...; Kumari, Meena; Langenberg, Clau ...; Lehtimaki, Terho; Lin, Shih-Yi; Lindstrom, Jaana; Loos, Ruth J. F.; Mach, Francois; McArdle, Wendy L ...; Meisinger, Chris ...; Mitchell, Braxto ...; Mueller, Gabriel ...; Nagaraja, Ramaia ...; Narisu, Narisu; Nieminen, Tuomo ...; Nsubuga, Rebecca ...; Olafsson, Isleif ...; Ong, Ken K.; Palotie, Aarno; Papamarkou, Theo ...; Pomilla, Cristin ...; Pouta, Anneli; Rader, Daniel J.; Reilly, Muredach ...; Ridker, Paul M.; Rivadeneira, Fer ...; Rudan, Igor; Ruokonen, Aimo; Samani, Nilesh; Scharnagl, Huber ...; Seeley, Janet; Silander, Kaisa; Stancakova, Alen ...; Stirrups, Kathle ...; Swift, Amy J.; Tiret, Laurence; Uitterlinden, An ...; van Pelt, L. Joo ...; Vedantam, Sailaj ...; Wainwright, Nich ...; Wijmenga, Cisca; Wild, Sarah H.; Willemsen, Gonne ...; Wilsgaard, Tom; Wilson, James F.; Young, Elizabeth ...; Zhao, Jing Hua; Adair, Linda S.; Arveiler, Domini ...; Assimes, Themist ...; Bandinelli, Stef ...; Bennett, Frankly ...; Bochud, Murielle; Boehm, Bernhard ...; Boomsma, Dorret ...; Borecki, Ingrid ...; Bornstein, Stefa ...; Bovet, Pascal; Burnier, Michel; Campbell, Harry; Chakravarti, Ara ...; Chambers, John C ...; Chen, Yii-Der Id ...; Collins, Francis ...; Cooper, Richard ...; Danesh, John; Dedoussis, Georg ...; de Faire, Ulf; Feranil, Alan B.; Ferrieres, Jean; Ferrucci, Luigi; Freimer, Nelson ...; Gieger, Christia ...; Groop, Leif; Gudnason, Vilmun ...; Gyllensten, Ulf; Hamsten, Anders; Harris, Tamara B ...; Hingorani, Aroon; Hirschhorn, Joel ...; Hofman, Albert; Hovingh, G. Kees; Hsiung, Chao Agn ...; Humphries, Steve ...; Hunt, Steven C.; Hveem, Kristian; Iribarren, Carlo ...; Jarvelin, Marjo- ...; Jula, Antti; Kahonen, Mika; Kaprio, Jaakko; Kesaniemi, Anter ...; Kivimaki, Mika; Kooner, Jaspal S ...; Koudstaal, Peter ...; Krauss, Ronald M ...; Kuh, Diana; Kuusisto, Johann ...; Kyvik, Kirsten O ...; Laakso, Markku; Lakka, Timo A.; Lindgren, Cecili ...; Martin, Nicholas ...; Maerz, Winfried; McCarthy, Mark I ...; McKenzie, Colin ...; Meneton, Pierre; Metspalu, Andres; Moilanen, Leena; Morris, Andrew D ...; Munroe, Patricia ...; Njolstad, Inger; Pedersen, Nancy ...; Power, Chris; Pramstaller, Pet ...; Price, Jackie F.; Psaty, Bruce M.; Quertermous, Tho ...; Rauramaa, Rainer; Saleheen, Danish; Salomaa, Veikko; Sanghera, Dharam ...; Saramies, Jouko; Schwarz, Peter E ...; Sheu, Wayne H-H; Shuldiner, Alan ...; Siegbahn, Agneta; Spector, Tim D.; Stefansson, Kari; Strachan, David ...; Tayo, Bamidele O ...; Tremoli, Elena; Tuomilehto, Jaak ...; Uusitupa, Matti; van Duijn, Corne ...; Vollenweider, Pe ...; Wallentin, Lars; Wareham, Nichola ...; Whitfield, John ...; Wolffenbuttel, B ...; Ordovas, Jose M.; Boerwinkle, Eric; Palmer, Colin N. ...; Thorsteinsdottir ...; Chasman, Daniel ...; Rotter, Jerome I ...; Franks, Paul; Ripatti, Samuli; Cupples, L. Adri ...; Sandhu, Manjinde ...; Rich, Stephen S.; Boehnke, Michael; Deloukas, Panos; Kathiresan, Seka ...; Mohlke, Karen L.; Ingelsson, Erik; Abecasis, Goncal ...; show less...

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