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Preserved Beta-Cell...
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Carlsson, Per-OlaUppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för medicinska vetenskaper
(författare)
Preserved Beta-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2014-09-09
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American Diabetes Association,2015
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-239511
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239511URI
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https://doi.org/10.2337/db14-0656DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130605987URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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De två sista författarna delar sistaförfattarskapet.
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The retention of endogenous insulin secretion in type 1 diabetes is an attractive clinical goal, which opens possibilities for long-term restoration of glucose metabolism. Mesenchymal stromal cells (MSCs) constitute, based on animal studies, a promising interventional strategy for the disease. This prospective clinical study describes the translation of this cellular intervention strategy to patients with recent onset type 1 diabetes. Twenty adult patients with newly diagnosed type 1 diabetes were enrolled and randomized to MSC treatment or to the control group. Residual beta-cell function was analyzed as C-peptide concentrations in blood in response to a mixed meal tolerance test (MMTT) at one-year follow-up. In contrast to the patients in the control arm, who showed loss in both C-peptide peak values and C-peptide when calculated as area under the curve during the first year, these responses were preserved or even increased in the MSC-treated patients. Importantly, no side effects of MSC treatment were observed. We conclude that autologous MSC treatment in new onset type 1 diabetes constitute a safe and promising strategy to intervene in disease progression and preserve beta-cell function.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Schwarcz, Erik
(författare)
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Korsgren, OlleUppsala universitet,Klinisk immunologi(Swepub:uu)ollekors
(författare)
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Le Blanc, KatarinaKarolinska Institutet
(författare)
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Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes: American Diabetes Association64:2, s. 587-5920012-17971939-327X
Internetlänk
Hitta via bibliotek
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Diabetes
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