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The Impact of Graft...
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Urbano-Ispizua, AlvaroUniv Barcelona, Hosp Clin, IDIBAPS, Dept Hematol, Barcelona, Spain.;Inst Res Josep Carreras, Barcelona, Spain.
(författare)
The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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Elsevier BV,2015
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-264815
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264815URI
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https://doi.org/10.1016/j.bbmt.2015.05.010DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132039712URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The purpose of this study was to analyze the impact of graft-versus-host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT). Adult patients with a diagnosis of Hodgkin lymphoma, diffuse large B cell lymphoma, follicular lymphoma (FL), peripheral T cell lymphoma, or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor hematopoietic cell transplantation between 1997 and 2009 were included. Two thousand six hundred eleven cases were included. A reduced-intensity conditioning (RIC) regimen was used in 62.8% of the transplantations. In a multivariate analysis of myeloablative cases (n = 970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n = 1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (risk ratio [RR],.51; P = 3.049) and in MCL (RR,.41; P = .019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR,.14; P = .007; and RR,.15; P = .0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment-related mortality and overall survival (OS) in FL cases but did not affect treatment-related mortality, OS or PFS in MCL. This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in FL and MCL patients.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pavletic, Steven Z.NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
(författare)
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Flowers, Mary E.Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA.
(författare)
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Klein, John P.Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
(författare)
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Zhang, Mei-JieMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
(författare)
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Carreras, JeanetteMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
(författare)
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Montoto, SilviaBarts Hlth NHS Trust, St Bartholomews Hosp, Dept Haematooncol, London, England.
(författare)
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Perales, Miguel-AngelMem Sloan Kettering Canc Ctr, Dept Med, Bone Marrow Transplant Serv, New York, NY 10021 USA.
(författare)
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Aljurf, Mahmoud D.King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
(författare)
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Akpek, GoerguenBanner MD Anderson Canc Ctr, Hematol Oncol Sect, Gilbert, AZ USA.
(författare)
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Bredeson, Christopher N.Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada.;Ottawa Hosp, Res Inst, Ottawa, ON, Canada.
(författare)
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Costa, Luciano J.Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
(författare)
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Dandoy, ChristopherCincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
(författare)
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Freytes, Cesar O.South Texas Vet Hlth Care Syst, San Antonio, TX USA.;Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
(författare)
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Fung, Henry C.Temple Hlth, Fox Chase Canc Ctr, Dept Med Oncol, Philadelphia, PA USA.
(författare)
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Gale, Robert PeterUniv London Imperial Coll Sci Technol & Med, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.
(författare)
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Gibson, JohnRoyal Prince Alfred Hosp, Inst Haematol, Camperdown, NSW 2050, Australia.
(författare)
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Hamadani, MehdiMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
(författare)
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Hayashi, Robert J.Washington Univ, Sch Med, Dept Pediat, Div Pediat Hematol Oncol, St Louis, MO 63110 USA.
(författare)
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Inamoto, YoshihiroFred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA.
(författare)
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Inwards, David J.Mayo Clin, Div Hematol, Rochester, MN USA.
(författare)
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Lazarus, Hillard M.Univ Hosp Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA.
(författare)
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Maloney, David G.Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA.
(författare)
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Martino, RodrigoHosp Santa Creu & Sant Pau, Div Hematol, Barcelona, Spain.
(författare)
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Munker, ReinholdLouisiana State Univ Hlth, Dept Internal Med, Div Hematol Oncol, Shreveport, LA USA.
(författare)
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Nishihori, TaigaUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Med Oncol, Tampa, FL 33612 USA.
(författare)
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Olsson, Richard F.Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.(Swepub:uu)riols677
(författare)
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Rizzieri, David A.Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.
(författare)
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Reshef, RanUniv Penn, Dept Med, Abramson Canc Ctr, Med Ctr, Philadelphia, PA 19104 USA.
(författare)
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Saad, AymanUniv Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
(författare)
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Savani, Bipin N.Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
(författare)
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Schouten, Harry C.Acad Ziekenhuis, Dept Hematol, Maastricht, Netherlands.
(författare)
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Smith, Sonali M.Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USA.
(författare)
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Socie, GerardHop St Louis, Dept Hematol, Paris, France.
(författare)
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Wirk, BaldeepSUNY Stony Brook, Med Ctr, Dept Internal Med, Stony Brook, NY 11794 USA.
(författare)
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Yu, Lolie C.Louisiana State Univ, Med Ctr, Childrens Hosp, Div Hematol Oncol,Ctr Canc & Blood Disorders, New Orleans, LA USA.
(författare)
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Saber, WaelMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
(författare)
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Univ Barcelona, Hosp Clin, IDIBAPS, Dept Hematol, Barcelona, Spain.;Inst Res Josep Carreras, Barcelona, Spain.NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biology of blood and marrow transplantation: Elsevier BV21:10, s. 1746-17531083-87911523-6536
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Till lärosätets databas
- Av författaren/redakt...
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Urbano-Ispizua, ...
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Pavletic, Steven ...
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Flowers, Mary E.
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Klein, John P.
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Zhang, Mei-Jie
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Carreras, Jeanet ...
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visa fler...
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Montoto, Silvia
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Perales, Miguel- ...
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Aljurf, Mahmoud ...
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Akpek, Goerguen
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Bredeson, Christ ...
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Costa, Luciano J ...
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Dandoy, Christop ...
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Freytes, Cesar O ...
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Fung, Henry C.
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Gale, Robert Pet ...
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Gibson, John
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Hamadani, Mehdi
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Hayashi, Robert ...
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Inamoto, Yoshihi ...
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Inwards, David J ...
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Lazarus, Hillard ...
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Maloney, David G ...
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Martino, Rodrigo
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Munker, Reinhold
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Nishihori, Taiga
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Olsson, Richard ...
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Rizzieri, David ...
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Reshef, Ran
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Saad, Ayman
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Savani, Bipin N.
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Schouten, Harry ...
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Smith, Sonali M.
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Socie, Gerard
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Wirk, Baldeep
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Yu, Lolie C.
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Saber, Wael
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Biology of blood ...
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Uppsala universitet
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