MRI and 11C acetate PET/CT for prediction of regional lymph node metastasis in newly diagnosed prostate cancer

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Background:C acetate PET/CT parameters in predicting regional lymph node (LN) metastasis of newly diagnosed prostate cancer (PCa).Patients and methods:C acetate PET/CT (53 patients) before extended pelvic LN dissection. For each patient the visually most suspicious LN was assessed for mean apparent diffusion coefficient (ADCmean), maximal standardized uptake value (SUVmax), size and shape and the primary tumour for T stage on MRI and ADCmean and SUVmax in the index lesion. The variables were analysed in simple and multiple logistic regression analysis.Results:All variables, except ADCmean and SUVmax of the primary tumor, were independent predictors of LN metastasis. In multiple logistic regression analysis the best model was ADCmean in combintion with MRI T-stage where both were independent predictors of LN metastasis, this combination had an AUC of 0.81 which was higher than the AUC of 0.65 for LN ADCmean alone and the AUC of 0.69 for MRI T-stage alone.Conclusions:Several quantitative and qualitative imaging parameters are predictive of regional LN metastasis in PCa. The combination of ADCmean in lymph nodes and T-stage on MRI was the best model in multiple logistic regression with increased predictive value compared to lymph node ADCmean and T-stage on MRI alone.

Wassberg, CeciliaUppsala universitet,Radiologi(Swepub:uu)ceciwass (författare)
Grzegorek, Rafael (författare)
Kullberg, Joel,1979-Uppsala universitet,Radiologi,Antaros Medical AB, Mölndal, Sweden(Swepub:uu)jokul377 (författare)
Gestblom, Charlotta (författare)
Sörensen, JensUppsala universitet,Radiologi(Swepub:uu)jenssore (författare)
Waldén, Mauritz (författare)
Ahlström, Håkan,1953-Uppsala universitet,Radiologi,Antaros Medical AB, Mölndal, Sweden(Swepub:uu)hakanahl (författare)
Uppsala universitetRadiologi (creator_code:org_t)

Ingår i:Radiology and Oncology: Walter de Gruyter GmbH52:1, s. 90-971318-20991581-3207

Av författaren/redakt...: von Below, Catri ...; Wassberg, Cecili ...; Grzegorek, Rafae ...; Kullberg, Joel, ...; Gestblom, Charlo ...; Sörensen, Jens; visa fler...; Waldén, Mauritz; Ahlström, Håkan, ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

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