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Virome characterisa...
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Bogdanovic, GKarolinska Institutet
(författare)
Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia.
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-08-23
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Springer Science and Business Media LLC,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-348263
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-348263URI
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https://doi.org/10.1038/bjc.2016.261DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134485241URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Some childhood acute lymphoblastic leukaemias (ALL) can be traced back to a prenatal origin, where a virus infection could be involved in the first pre-leukaemic clone development. The DNA virome of 95 children who later developed ALL was characterised from neonatal blood spots (NBS) using unbiased next-generation sequencing (NGS) and compared with the virome of 95 non-ALL controls.METHODS: DNA was individually extracted from the ALL-patients and controls, pooled, randomly amplified and sequenced using the Illumina MiSeq Sequencing System.RESULTS: Virus-like sequences identified in both groups mapped to human endogenous retroviruses and propionibacterium phage, considered a part of the normal microbial flora. Potential pathogens human herpesvirus type 6 (HHV-6) and parvovirus B19 were also identified, but only few samples in both ALL and controls tested positive by PCR follow-up.CONCLUSIONS: Unbiased NGS was employed to search for DNA from potential infectious agents in neonatal samples of children who later developed ALL. Although several viral candidates were identified in the NBS samples, further investigation by PCR suggested that these viruses did not have a major role in ALL development.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pou, CKarolinska Institutet
(författare)
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Barrientos-Somarribas, MKarolinska Institutet
(författare)
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Bjerkner, AKarolinska Institutet
(författare)
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Honkaniemi, EKarolinska Institutet
(författare)
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Allander, TKarolinska Institutet
(författare)
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Andersson, BDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
(författare)
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Gustafsson, BDepartment of Clinical Science, Intervention and Technology, CLINTEC, Karolinska Institutet, Stokholm, Sweden(Swepub:uu)brigu929
(författare)
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Karolinska InstitutetDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Cancer: Springer Science and Business Media LLC115:8, s. 1008-10140007-09201532-1827
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