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Sökning: onr:"swepub:oai:DiVA.org:uu-369767" > Fatty acid biomarke...

  • Imamura, FumiakiUniv Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England (författare)

Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes : A pooled analysis of prospective cohort studies

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-10-10
  • Public Library of Science (PLoS),2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-369767
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369767URI
  • https://doi.org/10.1371/journal.pmed.1002670DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15: 0 and 17: 0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D). Methods and findings Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, tri-glycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men ((pinteraction) < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist. Conclusions In a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Fretts, AmandaUniv Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA (författare)
  • Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)matma701 (författare)
  • Korat, Andres V. ArdissonHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA (författare)
  • Yang, Wei-SinNatl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan (författare)
  • Lankinen, MariaUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland (författare)
  • Qureshi, WaqasWake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Bowman Gray Ctr,Sect Cardiovasc Med, Winston Salem, NC 27103 USA (författare)
  • Helmer, CatherineUniv Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France (författare)
  • Chen, Tzu-AnUSDA ARS, Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX USA (författare)
  • Wong, KerryCanc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia (författare)
  • Bassett, Julie K.Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia (författare)
  • Murphy, RachelUniv British Columbia, Fac Med, Sch Populat & Publ Hlth, Ctr Excellence Canc Prevent, Vancouver, BC, Canada (författare)
  • Tintle, NathanDordt Coll, Dept Math & Stat, Sioux Ctr, IA USA (författare)
  • Yu, Chaoyu IanUniv Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA (författare)
  • Brouwer, Ingeborg A.Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Fac Earth & Life Sci, Dept Hlth Sci, Amsterdam, Netherlands (författare)
  • Chien, Kuo-LiongNatl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan (författare)
  • Frazier-Wood, Alexis C.USDA ARS, Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX USA (författare)
  • del Gobbo, Liana C.Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA USA (författare)
  • Djousse, LucBrigham & Womens Hosp, Dept Med, Div Aging, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA (författare)
  • Geleijnse, Johanna M.Wageningen Univ, Div Human Nutr, Wageningen, Netherlands (författare)
  • Giles, Graham G.Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia (författare)
  • de Goede, JanetteWageningen Univ, Div Human Nutr, Wageningen, Netherlands (författare)
  • Gudnason, VilmundurIceland Heart Assoc Res Inst, Kopavogur, Iceland (författare)
  • Harris, William S.Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA;OmegaQuant Analyt LLC, Sioux Falls, SD USA (författare)
  • Hodge, AllisonCanc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia (författare)
  • Hu, FrankHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA (författare)
  • Koulman, AlbertUniv Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England;Univ Cambridge, Addenbrookes Hosp, Natl Inst Hlth Res Biomed Res Ctr Core Nutr Bioma, Cambridge, England;Univ Cambridge, Addenbrookes Hosp, Natl Inst Hlth Res Biomed Res Ctr Core Metabol &, Cambridge, England;MRC, Elsie Widdowson Lab, Cambridge, England;Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland (författare)
  • Laakso, MarkkuKuopio Univ Hosp, Dept Med, Kuopio, Finland (författare)
  • Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larslind (författare)
  • Lin, Hung-JuNatl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan (författare)
  • McKnight, BarbaraUniv Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA (författare)
  • Rajaobelina, KalinaUniv Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France (författare)
  • Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism,Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, Uppsala, Sweden(Swepub:uu)ulfriser (författare)
  • Robinson, Jennifer G.Univ Iowa, Dept Epidemiol, Coll Publ Hlth, Iowa City, IA USA;Univ Iowa, Dept Med, Coll Publ Hlth, Iowa City, IA 52242 USA (författare)
  • Samieri, CeciliaUniv Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France (författare)
  • Siscovick, David S.New York Acad Med, New York, NY USA (författare)
  • Soedamah-Muthu, Sabita S.Tilburg Univ, Ctr Res Psychol Somat Dis, Dept Med & Clin Psychol, Tilburg, Netherlands (författare)
  • Sotoodehnia, NonaUniv Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA (författare)
  • Sun, QiHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA (författare)
  • Tsai, Michael Y.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA (författare)
  • Uusitupa, MattiUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland (författare)
  • Wagenknecht, Lynne E.Wake Forest Sch Med, Publ Hlth Sci, Winston Salem, NC USA (författare)
  • Wareham, Nick J.Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England (författare)
  • Wu, Jason H. Y.Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia (författare)
  • Micha, RenataTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA (författare)
  • Forouhi, Nita G.Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England (författare)
  • Lemaitre, Rozenn N.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA (författare)
  • Mozaffarian, DariushTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA (författare)
  • Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, EnglandUniv Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLoS Medicine: Public Library of Science (PLoS)15:101549-12771549-1676

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