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  • Teras, Lauren R.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. (author)

Body size and multiple myeloma mortality : a pooled analysis of 20 prospective studies

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-05-23
  • WILEY-BLACKWELL,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-421977
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421977URI
  • https://doi.org/10.1111/bjh.12935DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:129605218URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1.5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1.22, 95% CI: 1.09-1.35 per 5 kg/m(2)) and for higher cohort-entry BMI (HR 1.09, 95% CI: 1.03-1.16 per 5 kg/m(2)) and waist circumference (HR = 1.06, 95% CI: 1.02-1.10 per 5 cm). In analyses of the joint effect of young adult and baseline BMI, women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18.5 = 25 at both time points (HR = 1.95, 95% CI: 1.33-2.86) but there was no significant association in men. Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kitahara, Cari M.NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Birmann, Brenda M.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA. (author)
  • Hartge, Patricia A.NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Wang, Sophia S.City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA USA. (author)
  • Robien, KimGeorge Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Epidemiol & Biostat, Washington, DC USA. (author)
  • Patel, Alpa V.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. (author)
  • Adami, Hans-OlovKarolinska Institutet (author)
  • Weiderpass, ElisabeteKarolinska Institutet (author)
  • Giles, Graham G.Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia. (author)
  • Singh, Pramil N.Loma Linda Univ, Sch Publ Hlth, Ctr Hlth Res, Loma Linda, CA 92350 USA. (author)
  • Alavanja, MichaelNCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Freeman, Laura E. BeaneNCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Bernstein, LeslieCity Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA USA. (author)
  • Buring, Julie E.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA. (author)
  • Colditz, Graham A.Washington Univ, Sch Med, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA. (author)
  • Fraser, Gary E.Loma Linda Univ, Sch Publ Hlth, Ctr Hlth Res, Loma Linda, CA 92350 USA. (author)
  • Gapstur, Susan M.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. (author)
  • Gaziano, J. MichaelBrigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA.;Boston VA Med Ctr, Boston, MA USA. (author)
  • Giovannucci, EdwardBrigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. (author)
  • Hofmann, Jonathan N.NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Linet, Martha S.NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Neta, GilaNCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Park, YikyungNCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Peters, Ulrike (author)
  • Rosenberg, Philip S.NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Schairer, CatherineNCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Sesso, Howard D.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA. (author)
  • Stampfer, Meir J.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. (author)
  • Visvanathan, KalaJohns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.;Johns Hopkins Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA. (author)
  • White, EmilyFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. (author)
  • Wolk, AlicjaKarolinska Institutet (author)
  • Zeleniuch-Jacquotte, AnneNYU, Dept Environm Med, Sch Med, Div Epidemiol, New York, NY 10016 USA. (author)
  • de Gonzalez, Amy BerringtonNCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Purdue, Mark P.NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (author)
  • Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD USA. (creator_code:org_t)

Related titles

  • In:British Journal of Haematology: WILEY-BLACKWELL166:5, s. 667-6760007-10481365-2141

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