Search: onr:"swepub:oai:gup.ub.gu.se/298297" >
The genetic archite...
The genetic architecture of sporadic and multiple consecutive miscarriage.
- Article/chapterEnglish2020
Publisher, publication year, extent ...
-
2020-11-25
-
Springer Science and Business Media LLC,2020
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/298297
-
https://gup.ub.gu.se/publication/298297URI
-
https://doi.org/10.1038/s41467-020-19742-5DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 750 cases of European ancestry for multiple (≥3) consecutive miscarriage, and up to 359,469 female controls. We identify one genome-wide significant association (rs146350366, minor allele frequency (MAF) 1.2%, P=3.2 × 10-8, odds ratio (OR)=1.4) for sporadic miscarriage in our European ancestry meta-analysis and three genome-wide significant associations for multiple consecutive miscarriage (rs7859844, MAF=6.4%, P=1.3 × 10-8, OR=1.7; rs143445068, MAF=0.8%, P=5.2 × 10-9, OR=3.4; rs183453668, MAF=0.5%, P=2.8 × 10-8, OR=3.8). We further investigate the genetic architecture of miscarriage with biobank-scale Mendelian randomization, heritability, and genetic correlation analyses. Our results show that miscarriage etiopathogenesis is partly driven by genetic variation potentially related to placental biology, and illustrate the utility of large-scale biobank data for understanding this pregnancy complication.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Soares, Ana Luiza G
(author)
-
Ferreira, Teresa
(author)
-
Painter, Jodie N
(author)
-
Censin, Jenny C
(author)
-
Laber, Samantha
(author)
-
Bacelis, Jonas
(author)
-
Chen, Chia-Yen
(author)
-
Lepamets, Maarja
(author)
-
Lin, Kuang
(author)
-
Liu, Siyang
(author)
-
Millwood, Iona Y
(author)
-
Ramu, Avinash
(author)
-
Southcombe, Jennifer
(author)
-
Andersen, Marianne S
(author)
-
Yang, Ling
(author)
-
Becker, Christian M
(author)
-
Børglum, Anders D
(author)
-
Gordon, Scott D
(author)
-
Bybjerg-Grauholm, Jonas
(author)
-
Helgeland, Øyvind
(author)
-
Hougaard, David M
(author)
-
Jin, Xin
(author)
-
Johansson, Stefan
(author)
-
Juodakis, JuliusGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjouju
(author)
-
Kartsonaki, Christiana
(author)
-
Kukushkina, Viktorija
(author)
-
Lind, Penelope A
(author)
-
Metspalu, Andres
(author)
-
Montgomery, Grant W
(author)
-
Morris, Andrew P
(author)
-
Mors, Ole
(author)
-
Mortensen, Preben B
(author)
-
Njølstad, Pål R
(author)
-
Nordentoft, Merete
(author)
-
Nyholt, Dale R
(author)
-
Lippincott, Margaret
(author)
-
Seminara, Stephanie
(author)
-
Salumets, Andres
(author)
-
Snieder, Harold
(author)
-
Zondervan, Krina
(author)
-
Werge, Thomas
(author)
-
Chen, Zhengming
(author)
-
Conrad, Donald F
(author)
-
Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo
(author)
-
Li, Liming
(author)
-
Martin, Nicholas G
(author)
-
Neale, Benjamin M
(author)
-
Nielsen, Rasmus
(author)
-
Walters, Robin G
(author)
-
Granne, Ingrid
(author)
-
Medland, Sarah E
(author)
-
Mägi, Reedik
(author)
-
Lawlor, Deborah A
(author)
-
Lindgren, Cecilia M
(author)
-
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
(creator_code:org_t)
Related titles
-
In:Nature communications: Springer Science and Business Media LLC11:12041-1723
Internet link
Find in a library
To the university's database
- By the author/editor
-
Laisk, Triin
-
Soares, Ana Luiz ...
-
Ferreira, Teresa
-
Painter, Jodie N
-
Censin, Jenny C
-
Laber, Samantha
-
show more...
-
Bacelis, Jonas
-
Chen, Chia-Yen
-
Lepamets, Maarja
-
Lin, Kuang
-
Liu, Siyang
-
Millwood, Iona Y
-
Ramu, Avinash
-
Southcombe, Jenn ...
-
Andersen, Marian ...
-
Yang, Ling
-
Becker, Christia ...
-
Børglum, Anders ...
-
Gordon, Scott D
-
Bybjerg-Grauholm ...
-
Helgeland, Øyvin ...
-
Hougaard, David ...
-
Jin, Xin
-
Johansson, Stefa ...
-
Juodakis, Julius
-
Kartsonaki, Chri ...
-
Kukushkina, Vikt ...
-
Lind, Penelope A
-
Metspalu, Andres
-
Montgomery, Gran ...
-
Morris, Andrew P
-
Mors, Ole
-
Mortensen, Prebe ...
-
Njølstad, Pål R
-
Nordentoft, Mere ...
-
Nyholt, Dale R
-
Lippincott, Marg ...
-
Seminara, Stepha ...
-
Salumets, Andres
-
Snieder, Harold
-
Zondervan, Krina
-
Werge, Thomas
-
Chen, Zhengming
-
Conrad, Donald F
-
Jacobsson, Bo, 1 ...
-
Li, Liming
-
Martin, Nicholas ...
-
Neale, Benjamin ...
-
Nielsen, Rasmus
-
Walters, Robin G
-
Granne, Ingrid
-
Medland, Sarah E
-
Mägi, Reedik
-
Lawlor, Deborah ...
-
Lindgren, Cecili ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
Nature communica ...
- By the university
-
University of Gothenburg