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  • Viale, Giuseppe (author)

Chemoendocrine compared with endocrine adjuvant therapies for node-negative breast cancer: predictive value of centrally reviewed expression of estrogen and progesterone receptors--International Breast Cancer Study Group.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2008

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/82588
  • https://gup.ub.gu.se/publication/82588URI
  • https://doi.org/10.1200/JCO.2007.10.6393DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PURPOSE: To centrally assess estrogen receptor (ER) and progesterone receptor (PgR) levels by immunohistochemistry and investigate their predictive value for benefit of chemo-endocrine compared with endocrine adjuvant therapy alone in two randomized clinical trials for node-negative breast cancer. PATIENTS AND METHODS: International Breast Cancer Study Group Trial VIII compared cyclophosphamide, methotrexate, and fluorouracil (CMF) chemotherapy for 6 cycles followed by endocrine therapy with goserelin with either modality alone in pre- and perimenopausal patients. Trial IX compared three cycles of CMF followed by tamoxifen for 5 years versus tamoxifen alone in postmenopausal patients. Central Pathology Office reviewed 883 (83%) of 1,063 patients on Trial VIII and 1,365 (82%) of 1,669 on Trial IX and determined ER and PgR by immunohistochemistry. Disease-free survival (DFS) was compared across the spectrum of expression of each receptor using the Subpopulation Treatment Effect Pattern Plot methodology. RESULTS: Both receptors displayed a bimodal distribution, with substantial proportions showing no staining (receptor absent) and most of the remainder showing a high percentage of stained cells. Chemo-endocrine therapy yielded DFS superior to endocrine therapy alone for patients with receptor-absent tumors, and in some cases also for those with low levels of receptor expression. Among patients with ER-expressing tumors, additional prediction of benefit was suggested in absent or low PgR in Trial VIII but not in Trial IX. CONCLUSION: Low levels of ER and PgR are predictive of the benefit of adding chemotherapy to endocrine therapy. Low PgR may add further prediction among pre- and perimenopausal but not postmenopausal patients whose tumors express ER.

Subject headings and genre

  • MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
  • MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
  • Adult
  • Aged
  • Antineoplastic Agents
  • Hormonal
  • therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols
  • administration & dosage
  • therapeutic use
  • Breast Neoplasms
  • chemistry
  • drug therapy
  • surgery
  • Chemotherapy
  • Adjuvant
  • Cyclophosphamide
  • administration & dosage
  • Disease-Free Survival
  • Female
  • Fluorouracil
  • administration & dosage
  • Goserelin
  • administration & dosage
  • Humans
  • Immunohistochemistry
  • Menopause
  • Methotrexate
  • administration & dosage
  • Middle Aged
  • Neoplasms
  • Hormone-Dependent
  • chemistry
  • drug therapy
  • Predictive Value of Tests
  • Receptors
  • Estrogen
  • analysis
  • Receptors
  • Progesterone
  • analysis
  • Tamoxifen
  • administration & dosage
  • Treatment Outcome
  • Tumor Markers
  • Biological
  • analysis

Added entries (persons, corporate bodies, meetings, titles ...)

  • Regan, Meredith M (author)
  • Maiorano, Eugenio (author)
  • Mastropasqua, Mauro G (author)
  • Golouh, Rastko (author)
  • Perin, Tiziana (author)
  • Brown, Robert W (author)
  • Kovács, Anikó,1961Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xkovan (author)
  • Pillay, Komala (author)
  • Ohlschlegel, Christian (author)
  • Braye, Stephen (author)
  • Grigolato, Piergiovanni (author)
  • Rusca, Tiziana (author)
  • Gelber, Richard D (author)
  • Castiglione-Gertsch, Monica (author)
  • Price, Karen N (author)
  • Goldhirsch, Aron (author)
  • Gusterson, Barry A (author)
  • Coates, Alan S (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)

Related titles

  • In:Journal of clinical oncology : official journal of the American Society of Clinical Oncology26:9, s. 1404-101527-7755

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