Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

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Huth, Cornelia (author)

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.

Article/chapterEnglish2009

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2009-07-08
Informa UK Limited,2009

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LIBRIS-ID:oai:gup.ub.gu.se/93821
https://gup.ub.gu.se/publication/93821URI
https://doi.org/10.1080/07853890802337037DOI
https://lup.lub.lu.se/record/1372595URI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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BACKGROUND: Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. AIMS: This joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). METHODS: Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. RESULTS: The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G>C and BMI or interleukin-6 levels, except in some subgroups. CONCLUSIONS: Our data suggest that C-allele carriers of the IL6 -174G>C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Blood Glucose
analysis
Body Mass Index
Diabetes Mellitus
Type 2
blood
epidemiology
genetics
physiopathology
Epidemiology
Molecular
Humans
Interleukin-6
blood
genetics
Phenotype
Polymorphism
Single Nucleotide
meta-analysis
molecular epidemiology
single nucleotide polymorphism
intermediate phenotype
interleukin-6
inflammation mediators
genes
diabetes mellitus type 2
Blood glucose
body mass index

Added entries (persons, corporate bodies, meetings, titles ...)

Illig, Thomas (author)
Herder, Christian (author)
Gieger, Christian (author)
Grallert, Harald (author)
Vollmert, Caren (author)
Rathmann, Wolfgang (author)
Hamid, Yasmin H (author)
Pedersen, Oluf (author)
Hansen, Torben (author)
Thorand, Barbara (author)
Meisinger, Christa (author)
Doring, Angela (author)
Klopp, Norman (author)
Gohlke, Henning (author)
Lieb, Wolfgang (author)
Hengstenberg, Christian (author)
Lyssenko, Valeriya (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Ireland, Helen (author)
Stephens, Jeffrey W (author)
Wernstedt Asterholm, IngridGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xwerni (author)
Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xjanjo (author)
Boeing, Heiner (author)
Mohlig, Matthias (author)
Stringham, Heather M (author)
Boehnke, Michael (author)
Tuomilehto, Jaakko (author)
Fernandez-Real, Jose-Manuel (author)
Lopez-Bermejo, Abel (author)
Gallart, Luis (author)
Vendrell, Joan (author)
Humphries, Steve E (author)
Kronenberg, Florian (author)
Wichmann, H-Erich (author)
Heid, Iris M (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Annals of medicine: Informa UK Limited41:2, s. 128-381365-20600785-3890

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

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