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Common variation at...
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
- Article/chapterEnglish2013
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2013-08-18
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Springer Science and Business Media LLC,2013
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LIBRIS-ID:oai:lup.lub.lu.se:0130c0d9-1d4a-48b1-86f1-1f9070f7de4e
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https://lup.lub.lu.se/record/4172070URI
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https://doi.org/10.1038/ng.2733DOI
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Language:English
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Summary in:English
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To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 x 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.
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Weinhold, Niels
(author)
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Broderick, Peter
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Chen, Bowang
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Johnson, David C.
(author)
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Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-asf
(author)
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Vijayakrishnan, Jayaram
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Migliorini, Gabriele
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Dobbins, Sara E.
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Holroyd, Amy
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Hose, Dirk
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Walker, Brian A.
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Davies, Faith E.
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Gregory, Walter A.
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Jackson, Graham H.
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Irving, Julie A.
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Pratt, Guy
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Fegan, Chris
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Fenton, James A. L.
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Neben, Kai
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Hoffmann, Per
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Noethen, Markus M.
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Muehleisen, Thomas W.
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Eisele, Lewin
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Ross, Fiona M.
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Straka, Christian
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Einsele, Hermann
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Langer, Christian
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Doerner, Elisabeth
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Allan, James M.
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Jauch, Anna
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Morgan, Gareth J.
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Hemminki, Kari
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Houlston, Richard S.
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Goldschmidt, Hartmut
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Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC45:10, s. 366-12211546-17181061-4036
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Chubb, Daniel
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Weinhold, Niels
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Broderick, Peter
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Chen, Bowang
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Johnson, David C ...
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Försti, Asta
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Vijayakrishnan, ...
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Migliorini, Gabr ...
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Dobbins, Sara E.
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Holroyd, Amy
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Hose, Dirk
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Walker, Brian A.
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Davies, Faith E.
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Gregory, Walter ...
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Jackson, Graham ...
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Irving, Julie A.
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Pratt, Guy
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Fegan, Chris
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Fenton, James A. ...
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Neben, Kai
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Hoffmann, Per
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Noethen, Markus ...
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Muehleisen, Thom ...
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Eisele, Lewin
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Ross, Fiona M.
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Straka, Christia ...
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Einsele, Hermann
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Langer, Christia ...
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Doerner, Elisabe ...
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Allan, James M.
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Jauch, Anna
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Morgan, Gareth J ...
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Hemminki, Kari
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Houlston, Richar ...
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Goldschmidt, Har ...
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Nature Genetics
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Lund University