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Meta-analysis ident...
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Ellinor, Patrick T.
(author)
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-04-29
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Springer Science and Business Media LLC,2012
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:13666abe-844c-465c-877e-0c7b0f3582c4
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https://lup.lub.lu.se/record/2906770URI
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https://doi.org/10.1038/ng.2261DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
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Lunetta, Kathryn L.
(author)
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Albert, Christine M.
(author)
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Glazer, Nicole L.
(author)
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Ritchie, Marylyn D.
(author)
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Smith, Albert V.
(author)
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Arking, Dan E.
(author)
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Mueller-Nurasyid, Martina
(author)
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Krijthe, Bouwe P.
(author)
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Lubitz, Steven A.
(author)
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Bis, Joshua C.
(author)
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Chung, Mina K.
(author)
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Doerr, Marcus
(author)
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Ozaki, Kouichi
(author)
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Roberts, Jason D.
(author)
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Smith, GustavLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)med-gvs
(author)
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Pfeufer, Arne
(author)
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Sinner, Moritz F.
(author)
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Lohman, Kurt
(author)
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Ding, Jingzhong
(author)
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Smith, Nicholas L.
(author)
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Smith, Jonathan D.
(author)
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Rienstra, Michiel
(author)
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Rice, Kenneth M.
(author)
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Van Wagoner, David R.
(author)
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Magnani, Jared W.
(author)
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Wakili, Reza
(author)
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Clauss, Sebastian
(author)
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Rotter, Jerome I.
(author)
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Steinbeck, Gerhard
(author)
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Launer, Lenore J.
(author)
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Davies, Robert W.
(author)
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Borkovich, Matthew
(author)
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Harris, Tamara B.
(author)
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Lin, Honghuang
(author)
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Voelker, Uwe
(author)
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Voelzke, Henry
(author)
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Milan, David J.
(author)
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Hofman, Albert
(author)
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Boerwinkle, Eric
(author)
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Chen, Lin Y.
(author)
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Soliman, Elsayed Z.
(author)
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Voight, Benjamin F.
(author)
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Li, Guo
(author)
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Chakravarti, Aravinda
(author)
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Kubo, Michiaki
(author)
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Tedrow, Usha B.
(author)
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Rose, Lynda M.
(author)
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Ridker, Paul M.
(author)
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Conen, David
(author)
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Tsunoda, Tatsuhiko
(author)
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Furukawa, Tetsushi
(author)
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Sotoodehnia, Nona
(author)
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Xu, Siyan
(author)
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Kamatani, Naoyuki
(author)
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Levy, Daniel
(author)
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Nakamura, Yusuke
(author)
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Parvez, Babar
(author)
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Mahida, Saagar
(author)
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Furie, Karen L.
(author)
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Rosand, Jonathan
(author)
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Muhammad, Raafia
(author)
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Psaty, Bruce M.
(author)
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Meitinger, Thomas
(author)
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Perz, Siegfried
(author)
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Wichmann, H-Erich
(author)
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Witteman, Jacqueline C. M.
(author)
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Kao, W. H. Linda
(author)
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Kathiresan, Sekar
(author)
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Roden, Dan M.
(author)
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Uitterlinden, Andre G.
(author)
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Rivadeneira, Fernando
(author)
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McKnight, Barbara
(author)
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Sjögren, MarketaLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-msj
(author)
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Newman, Anne B.
(author)
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Liu, Yongmei
(author)
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Gollob, Michael H.
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Tanaka, Toshihiro
(author)
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Stricker, Bruno H. Ch
(author)
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Felix, Stephan B.
(author)
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Alonso, Alvaro
(author)
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Darbar, Dawood
(author)
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Barnard, John
(author)
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Chasman, Daniel I.
(author)
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Heckbert, Susan R.
(author)
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Benjamin, Emelia J.
(author)
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Gudnason, Vilmundur
(author)
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Kaeaeb, Stefan
(author)
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Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC44:6, s. 88-6701546-17181061-4036
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Ellinor, Patrick ...
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Lunetta, Kathryn ...
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Albert, Christin ...
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Glazer, Nicole L ...
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Ritchie, Marylyn ...
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Smith, Albert V.
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show more...
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Arking, Dan E.
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Mueller-Nurasyid ...
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Krijthe, Bouwe P ...
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Lubitz, Steven A ...
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Bis, Joshua C.
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Chung, Mina K.
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Doerr, Marcus
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Ozaki, Kouichi
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Roberts, Jason D ...
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Smith, Gustav
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Pfeufer, Arne
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Sinner, Moritz F ...
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Lohman, Kurt
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Ding, Jingzhong
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Smith, Nicholas ...
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Smith, Jonathan ...
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Rienstra, Michie ...
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Rice, Kenneth M.
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Van Wagoner, Dav ...
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Magnani, Jared W ...
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Wakili, Reza
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Clauss, Sebastia ...
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Rotter, Jerome I ...
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Steinbeck, Gerha ...
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Launer, Lenore J ...
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Davies, Robert W ...
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Borkovich, Matth ...
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Harris, Tamara B ...
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Lin, Honghuang
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Voelker, Uwe
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Voelzke, Henry
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Milan, David J.
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Hofman, Albert
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Boerwinkle, Eric
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Chen, Lin Y.
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Soliman, Elsayed ...
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Voight, Benjamin ...
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Li, Guo
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Chakravarti, Ara ...
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Kubo, Michiaki
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Tedrow, Usha B.
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Rose, Lynda M.
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Ridker, Paul M.
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Conen, David
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Tsunoda, Tatsuhi ...
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Furukawa, Tetsus ...
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Sotoodehnia, Non ...
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Xu, Siyan
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Kamatani, Naoyuk ...
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Levy, Daniel
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Nakamura, Yusuke
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Parvez, Babar
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Mahida, Saagar
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Furie, Karen L.
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Rosand, Jonathan
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Muhammad, Raafia
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Psaty, Bruce M.
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Meitinger, Thoma ...
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Perz, Siegfried
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Wichmann, H-Eric ...
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Witteman, Jacque ...
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Kao, W. H. Linda
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Kathiresan, Seka ...
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Roden, Dan M.
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Uitterlinden, An ...
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Rivadeneira, Fer ...
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McKnight, Barbar ...
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Sjögren, Marketa
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Newman, Anne B.
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Liu, Yongmei
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Gollob, Michael ...
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Melander, Olle
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Tanaka, Toshihir ...
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Stricker, Bruno ...
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Felix, Stephan B ...
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Alonso, Alvaro
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Darbar, Dawood
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Barnard, John
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Chasman, Daniel ...
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Heckbert, Susan ...
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Gudnason, Vilmun ...
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Kaeaeb, Stefan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Nature Genetics
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Lund University