Search: onr:"swepub:oai:lup.lub.lu.se:15b38a34-114a-492a-a053-3c96fffaf2cf" >
Steroid hormone mea...
Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies
- Article/chapterEnglish2015
Publisher, publication year, extent ...
-
Elsevier BV,2015
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:15b38a34-114a-492a-a053-3c96fffaf2cf
-
https://lup.lub.lu.se/record/7790641URI
-
https://doi.org/10.1016/j.steroids.2014.09.001DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Epidemiological studies have examined breast cancer risk in relation to sex hormone concentrations measured by different methods: "extraction" immunoassays (with prior purification by organic solvent extraction, with or without column chromatography), "direct" immunoassays (no prior extraction or column chromatography), and more recently with mass spectrometry-based assays. We describe the associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method, using data from a collaborative pooled analysis of 18 prospective studies. In general, hormone concentrations were highest in studies that used direct assays and lowest in studies that used mass spectrometry-based assays. Estradiol and estrone were strongly positively associated with body mass index, regardless of the assay method; testosterone was positively associated with body mass index for direct assays, but less clearly for extraction assays, and there were few data for mass spectrometry assays. The correlations of estradiol with body mass index, estrone and testosterone were lower for direct assays than for extraction and mass spectrometry assays, suggesting that the estimates from the direct assays were less precise. For breast cancer risk, all three hormones were strongly positively associated with risk regardless of assay method (except for testosterone by mass spectrometry where there were few data), with no statistically significant differences in the trends, but differences may emerge as new data accumulate. Future epidemiological and clinical research studies should continue to use the most accurate assays that are feasible within the design characteristics of each study.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Appleby, P. N.
(author)
-
Reeves, G. K.
(author)
-
Travis, R. C.
(author)
-
Brinton, L. A.
(author)
-
Dallal, C. M.
(author)
-
Helzlsouer, K. J.
(author)
-
Hoffman-Bolton, J.
(author)
-
Visvanathan, K.
(author)
-
Dorgan, J. F.
(author)
-
Falk, R. T.
(author)
-
Gapstur, S. M.
(author)
-
Gaudet, M. M.
(author)
-
Kaaks, R.
(author)
-
Riboli, E.
(author)
-
Rinaldi, S.
(author)
-
Key, T.
(author)
-
Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma
(author)
-
Hallmans, G.
(author)
-
Giles, G. G.
(author)
-
Le Marchand, L.
(author)
-
Kolonel, L. N.
(author)
-
Henderson, B. E.
(author)
-
Tworoger, S. S.
(author)
-
Hankinson, S. E.
(author)
-
Zeleniuch-Jacquotte, A.
(author)
-
Koenig, K.
(author)
-
Krogh, V.
(author)
-
Sieri, S.
(author)
-
Muti, P.
(author)
-
Ziegler, R. G.
(author)
-
Schairer, C.
(author)
-
Fuhrman, B. J.
(author)
-
Barrett-Connor, E.
(author)
-
Laughlin, G. A.
(author)
-
Grant, E. J.
(author)
-
Cologne, J.
(author)
-
Ohishi, W.
(author)
-
Hida, A.
(author)
-
Cauley, J. A.
(author)
-
Fourkala, E.-O.
(author)
-
Rohan, T. E.
(author)
-
Strickler, H. D.
(author)
-
Gunter, M. J.
(author)
-
KirurgiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Steroids: Elsevier BV99, s. 49-550039-128X
Internet link
Find in a library
-
Steroids
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Key, T. J.
-
Appleby, P. N.
-
Reeves, G. K.
-
Travis, R. C.
-
Brinton, L. A.
-
Dallal, C. M.
-
show more...
-
Helzlsouer, K. J ...
-
Hoffman-Bolton, ...
-
Visvanathan, K.
-
Dorgan, J. F.
-
Falk, R. T.
-
Gapstur, S. M.
-
Gaudet, M. M.
-
Kaaks, R.
-
Riboli, E.
-
Rinaldi, S.
-
Key, T.
-
Manjer, Jonas
-
Hallmans, G.
-
Giles, G. G.
-
Le Marchand, L.
-
Kolonel, L. N.
-
Henderson, B. E.
-
Tworoger, S. S.
-
Hankinson, S. E.
-
Zeleniuch-Jacquo ...
-
Koenig, K.
-
Krogh, V.
-
Sieri, S.
-
Muti, P.
-
Ziegler, R. G.
-
Schairer, C.
-
Fuhrman, B. J.
-
Barrett-Connor, ...
-
Laughlin, G. A.
-
Grant, E. J.
-
Cologne, J.
-
Ohishi, W.
-
Hida, A.
-
Cauley, J. A.
-
Fourkala, E.-O.
-
Rohan, T. E.
-
Strickler, H. D.
-
Gunter, M. J.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Steroids
- By the university
-
Lund University