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Molecular cytogenet...
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Micci, Francesca
(författare)
Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B cell malignancies
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2007-04-04
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Springer Science and Business Media LLC,2007
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:397dcdda-a631-4af5-9423-af25bb8cac42
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https://lup.lub.lu.se/record/662866URI
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https://doi.org/10.1007/s00428-007-0407-6DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Translocations involving an immunoglobulin (IG) locus are a recurring theme in B cell neoplasia. The rearrangements lead to the joining of an IG gene with a (proto)oncogene, whereby the latter comes under the influence of transcription-stimulating sequences in the constitutively active IG locus resulting in deregulation of the oncogene and neoplastic growth. We present here three cases of B cell neoplasia that showed a t(14;19)(q32;p13) by karyotypic analysis. Detailed molecular cytogenetic characterization of the breakpoints on chromosomes 14 and 19 in the two cases from which extra material was available, demonstrated the involvement of the immunoglobulin heavy-chain (IGH@)-variable region on chromosome 14 in both and, in one case, that the breakpoint was within the BRD4 gene on chromosome 19. Against the background of what one knows about IGH@ involvement in lymphatic malignancies, it is difficult to envisage a fusion gene with qualitatively altered protein product as the crucial pathogenetic outcome of the translocation. In spite of the fact that we found BRD4 split by the t(14;19)(q32;p13) in one of the two informative cases, we cannot be sure that this was the pathogenetically relevant target gene. Other pathogenetic possibilities could be deregulation of the neighboring NOTCH3 and/or ABHD9 genes, located distal to BRD4 in 19p13.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Panagopoulos, IoannisLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-ipa
(författare)
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Tjonnfjord, Geir E.
(författare)
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Kolstad, Arne
(författare)
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Delabie, Jan
(författare)
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Beiske, Klaus
(författare)
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Heim, Sverre
(författare)
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Avdelningen för klinisk genetikInstitutionen för laboratoriemedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Virchows Archiv: an international journal of pathology: Springer Science and Business Media LLC450:5, s. 559-5651432-2307
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Ingår i:Virchows Archiv: Springer Science and Business Media LLC450:5, s. 559-5650945-6317
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