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- Omar, BilalLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine (author)
Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2014-06-18
- Springer Science and Business Media LLC,2014
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- LIBRIS-ID:oai:lup.lub.lu.se:412919aa-64e6-4cd5-95fc-55c532a33c39
- https://lup.lub.lu.se/record/4528268URI
- https://doi.org/10.1007/s00125-014-3299-4DOI
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- Language:English
- Summary in:English
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- Inhibition of the enzyme dipeptidyl peptidase 4 (DPP-4), which cleaves and inactivates glucagon-like peptide 1 (GLP-1), is a glucose-lowering strategy in type 2 diabetes. Since DPP-4 is a ubiquitously distributed enzyme, we examined whether it is expressed in islets and whether an islet effect to inhibit DPP-4 may result in stimulated insulin secretion.
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- Liehua, Liu (author)
- Yamada, Yuchiro (author)
- Seino, Yutaka (author)
- Marchetti, Piero (author)
- Ahrén, BoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bah (author)
- Medicin, LundSektion II (creator_code:org_t)
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- In:Diabetologia: Springer Science and Business Media LLC57:9, s. 1876-18831432-04280012-186X
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- MEDICAL AND HEALTH SCIENCES
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