Sökning: onr:"swepub:oai:lup.lub.lu.se:5c02a673-d97c-479f-acfd-63c29e1ff802" >
Characteristics of ...
-
Tajar, Abdelouahid
(författare)
Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS).
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
-
The Endocrine Society,2012
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:5c02a673-d97c-479f-acfd-63c29e1ff802
-
https://lup.lub.lu.se/record/2431769URI
-
https://doi.org/10.1210/jc.2011-2513DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries. Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured. Results:Sixty-three men (2.1%) were classified as having LOH: 36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points. Conclusions:LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Huhtaniemi, Ilpo T
(författare)
-
O'Neill, Terence W
(författare)
-
Finn, Joseph D
(författare)
-
Pye, Stephen R
(författare)
-
Lee, David M
(författare)
-
Bartfai, György
(författare)
-
Boonen, Steven
(författare)
-
Casanueva, Felipe F F
(författare)
-
Forti, Gianni
(författare)
-
Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi
(författare)
-
Han, Thang S
(författare)
-
Kula, Krzysztof
(författare)
-
Labrie, Fernand
(författare)
-
Lean, Michael E J
(författare)
-
Pendleton, Neil
(författare)
-
Punab, Margus
(författare)
-
Vanderschueren, Dirk
(författare)
-
Wu, Frederick C W
(författare)
-
Reproduktionsmedicin, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:The Journal of clinical endocrinology and metabolism: The Endocrine Society97:5, s. 1508-15161945-71970021-972X
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tajar, Abdelouah ...
-
Huhtaniemi, Ilpo ...
-
O'Neill, Terence ...
-
Finn, Joseph D
-
Pye, Stephen R
-
Lee, David M
-
visa fler...
-
Bartfai, György
-
Boonen, Steven
-
Casanueva, Felip ...
-
Forti, Gianni
-
Giwercman, Aleks ...
-
Han, Thang S
-
Kula, Krzysztof
-
Labrie, Fernand
-
Lean, Michael E ...
-
Pendleton, Neil
-
Punab, Margus
-
Vanderschueren, ...
-
Wu, Frederick C ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
The Journal of c ...
- Av lärosätet
-
Lunds universitet