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Population-Based St...
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Malone, Kathleen E
(författare)
Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation in BRCA1 or BRCA2.
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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LIBRIS-ID:oai:lup.lub.lu.se:67190f37-9d28-4232-9d9f-4966a35d83cd
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https://lup.lub.lu.se/record/1595568URI
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https://doi.org/10.1200/JCO.2009.24.2495DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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PURPOSE: Women with breast cancer diagnosed early in life comprise a substantial portion of those tested for BRCA1/BRCA2 mutations; however, little information is available on the subsequent risks of contralateral breast cancer in mutation carriers. This study assessed the risk of subsequent contralateral breast cancer associated with carrying a BRCA1 or BRCA2 mutation. PATIENTS AND METHODS: In this nested case-control study, patients with contralateral breast cancer diagnosed 1 year or more after a first primary breast cancer (n = 705) and controls with unilateral breast cancer (n = 1,398) were ascertained from an underlying population-based cohort of 52,536 women diagnosed with a first invasive breast cancer before age 55 years. Interviews and medical record reviews were used to collect risk factor and treatment histories. All women were tested for BRCA1/BRCA2 mutations. Relative (rate ratios) and absolute (5- and 10-year cumulative) risks of developing contralateral breast cancer following a first invasive breast cancer were computed. RESULTS: Compared with noncarriers, BRCA1 and BRCA2 mutation carriers had 4.5-fold (95% CI, 2.8- to 7.1-fold) and 3.4-fold (95% CI, 2.0- to 5.8-fold) increased risks of contralateral breast cancer, respectively. The relative risk of contralateral breast cancer for BRCA1 mutation carriers increased as age of first diagnosis decreased. Age-specific cumulative risks are provided for clinical guidance. CONCLUSION: The risks of subsequent contralateral breast cancer are substantial for women who carry a BRCA1/BRCA2 mutation. These findings have important clinical relevance regarding the assessment of BRCA1/BRCA2 status in patients with breast cancer and the counseling and clinical management of patients found to carry a mutation.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Begg, Colin B
(författare)
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Haile, Robert W
(författare)
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Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-abo
(författare)
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Concannon, Patrick
(författare)
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Tellhed, LinaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ljo
(författare)
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Xue, Shanyan
(författare)
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Teraoka, Sharon
(författare)
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Bernstein, Leslie
(författare)
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Capanu, Marinela
(författare)
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Reiner, Anne S
(författare)
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Riedel, Elyn R
(författare)
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Thomas, Duncan C
(författare)
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Mellemkjær, Lene
(författare)
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Lynch, Charles F
(författare)
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Boice, John D
(författare)
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Anton-Culver, Hoda
(författare)
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Bernstein, Jonine L
(författare)
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Bröstcancer-genetikSektion I
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Clinical Oncology28, s. 2404-24101527-7755
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Malone, Kathleen ...
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Begg, Colin B
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Haile, Robert W
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Borg, Åke
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Concannon, Patri ...
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Tellhed, Lina
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visa fler...
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Xue, Shanyan
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Teraoka, Sharon
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Bernstein, Lesli ...
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Capanu, Marinela
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Reiner, Anne S
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Riedel, Elyn R
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Thomas, Duncan C
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Mellemkjær, Lene
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Lynch, Charles F
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Boice, John D
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Anton-Culver, Ho ...
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Bernstein, Jonin ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Lunds universitet