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Specific in vivo de...
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Viau, Muriel
(författare)
Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L
- Artikel/kapitelEngelska2004
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2004
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electronicrdacarrier
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LIBRIS-ID:oai:lup.lub.lu.se:741350e1-6841-4e3b-b148-4f26f1daddc1
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https://lup.lub.lu.se/record/141861URI
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https://doi.org/10.1128/IAI.72.6.3515-3523.2004DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense.
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Longo, Nancy S
(författare)
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Lipsky, Peter E
(författare)
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Björck, LarsLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)medk-lbj
(författare)
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Zouali, Moncef
(författare)
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InfektionsmedicinSektion III
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Infection and Immunity72:6, s. 3515-35231098-5522
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