SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:79229c20-c105-4e3d-b5d6-94a0818807a7"
 

Search: onr:"swepub:oai:lup.lub.lu.se:79229c20-c105-4e3d-b5d6-94a0818807a7" > Differential effect...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Abreu, Soraia CarvalhoUniversity of Vermont,Federal University of Rio de Janeiro (author)

Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • American Physiological Society,2020

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:79229c20-c105-4e3d-b5d6-94a0818807a7
  • https://lup.lub.lu.se/record/79229c20-c105-4e3d-b5d6-94a0818807a7URI
  • https://doi.org/10.1152/ajplung.00218.2020DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) lung disease as a model, the effects of ex vivo MSC exposure to clinical bronchoalveolar lavage fluid (BALF) samples, as a surrogate for the in vivo clinical lung environment, on MSC viability, gene expression, secreted cytokines, and mitochondrial function was compared to effects of BALF collected from healthy volunteers. CF BALF samples which cultured positive for Aspergillus sp. (Asp) induced rapid MSC death, usually within several hours of exposure. Further analyses suggested the fungal toxin gliotoxin as a potential mediator contributing to CF BALF-induced MSC death. RNA sequencing analyses of MSCs exposed to either Asp+ or Asp- CF BALF samples identified a number of differentially expressed transcripts, including those involved in interferon-signaling, anti-microbial gene expression, and cell death. Toxicity did not correlate with bacterial lung infections. These results suggest that the potential use of MSC-based cell therapies for CF or other lung diseases may not be warranted in the presence of Aspergillus.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hampton, Thomas HDartmouth College (author)
  • Hoffman, EvanUniversity of Vermont (author)
  • Dearborn, JacobUniversity of Vermont (author)
  • Ashare, AlixDartmouth College,Dartmouth-Hitchcock Medical Center (author)
  • Singh Sidhu, KaratatiwantUniversity of Vermont (author)
  • Matthews, Dwight EUniversity of Vermont (author)
  • McKenna, David H.University of Minnesota (author)
  • Amiel, EyalUniversity of Vermont (author)
  • Barua, JayitaUniversity of Vermont (author)
  • Krasnodembskaya, AnnaQueen's University Belfast (author)
  • English, KarenMaynooth University (author)
  • Mahon, Bernard PatrickMaynooth University (author)
  • Santos, Claudia DosSaint Michael's Hospital,University of Toronto (author)
  • Cruz, Fernanda FNational Institute of Science and Technology in Regenerative Medicine (INCT-REGENERA),Federal University of Rio de Janeiro (author)
  • Chambers, Daniel C.The Prince Charles Hospital,University of Queensland (author)
  • Liu, Kathleen DUniversity of California, San Francisco (author)
  • Matthay, Michael A.University of California, San Francisco (author)
  • Cramer, Robert ADartmouth College (author)
  • Stanton, Bruce ADartmouth College (author)
  • Rocco, Patricia R MNational Institute of Science and Technology in Regenerative Medicine (INCT-REGENERA),Federal University of Rio de Janeiro (author)
  • Wargo, Matthew J.University of Vermont (author)
  • Weiss, Daniel J.University of Vermont (author)
  • Rolandsson Enes, SaraLund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups,University of Vermont(Swepub:lu)med-sro (author)
  • University of VermontFederal University of Rio de Janeiro (creator_code:org_t)

Related titles

  • In:American Journal of Physiology: Lung Cellular and Molecular Physiology: American Physiological Society1040-06051522-1504

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view