SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:8262a611-bd0d-4e60-80f1-67293a607a58"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:8262a611-bd0d-4e60-80f1-67293a607a58" > Contralateral breas...

  • Bernstein, Jonine L. (författare)

Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: A WECARE Study Report

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2013

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:8262a611-bd0d-4e60-80f1-67293a607a58
  • https://lup.lub.lu.se/record/4062769URI
  • https://doi.org/10.1016/j.ejca.2013.04.028DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Women with germline BRCA1 or BRCA2 (BRCA1/BRCA2) mutations are at very high risk of developing breast cancer, including asynchronous contralateral breast cancer (CBC). BRCA1/BRCA2 genes help maintain genome stability and assist in DNA repair. We examined whether the risk of CBC associated with radiation treatment was higher among women with germline BRCA1/BRCA2 mutations than among non-carriers. Methods: A population-based, nested case-control study was conducted within a cohort of 52,536 survivors of unilateral breast cancer (UBC). Cases were 603 women with CBC and controls were 1199 women with UBC individually matched on age at diagnosis, race, year of first diagnosis and cancer registry. All women were tested for BRCA1 and BRCA2 mutations. Radiation absorbed dose from the initial radiotherapy (RT) to the CBC location within the contralateral breast was reconstructed from measurements in a tissue-equivalent phantom and details available in the therapy records. Findings: Among women treated with radiation, the mean radiation dose was 1.1 Gy (range = 0.02-6.2 Gy). Risk of developing CBC was elevated among women who carried a deleterious BRCA1/BRCA2 mutation (rate ratio, RR = 4.5, confidence interval, CI = 3.0-6.8), and also among those treated with RT (RR = 1.2, CI = 1.0-1.6). However, among mutation carriers, an incremental increase in risk associated with radiation dose was not statistically significant. Interpretation: Multiplicative interaction of RT with mutation status would be reflected by a larger association of RT with CBC among carriers than among non-carriers, but this was not apparent. Accordingly, there was no clear indication that carriers of deleterious BRCA/BRCA2 mutations were more susceptible to the carcinogenic effects of radiation than non-carriers. These findings are reassuring and have important clinical implications for treatment decisions and the clinical management of patients harbouring deleterious BRCA1/BRCA2 mutations. Funding: All work associated with this study was supported by the U.S. National Cancer Institute [R01CA097397, U01CA083178]. (C) 2013 Elsevier Ltd. All rights reserved.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Thomas, Duncan C. (författare)
  • Shore, Roy E. (författare)
  • Robson, Mark (författare)
  • Boice, John D. Jr. (författare)
  • Stovall, Marilyn (författare)
  • Andersson, Michael (författare)
  • Bernstein, Leslie (författare)
  • Malone, Kathleen E. (författare)
  • Reiner, Anne S. (författare)
  • Lynch, Charles F. (författare)
  • Capanu, Marinela (författare)
  • Smith, Susan A. (författare)
  • Tellhed, LinaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ljo (författare)
  • Teraoka, Sharon N. (författare)
  • Begg, Colin B. (författare)
  • Olsen, Jorgen H. (författare)
  • Mellemkjaer, Lene (författare)
  • Liang, Xiaolin (författare)
  • Diep, Anh T. (författare)
  • Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-abo (författare)
  • Concannon, Patrick (författare)
  • Haile, Robert W. (författare)
  • Bröstcancer-genetikSektion I (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Cancer: Elsevier BV49:14, s. 2979-29851879-08520959-8049

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy