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onr:"swepub:oai:lup.lub.lu.se:8315ffeb-7d67-47b8-bbdb-c5b90d4a3f49"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:8315ffeb-7d67-47b8-bbdb-c5b90d4a3f49" > Effect on mother an...

  • Gustavsen, AliceNorwegian Radium Hospital (författare)

Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:8315ffeb-7d67-47b8-bbdb-c5b90d4a3f49
  • https://lup.lub.lu.se/record/8315ffeb-7d67-47b8-bbdb-c5b90d4a3f49URI
  • https://doi.org/10.1097/MD.0000000000006338DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Rationale: Antiphospholipid syndrome (APS) in pregnancy may trigger the life-threatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is implicated in the pathogenesis, and inhibition of complement factor C5 is suggested as an additional treatment option. Patient concerns, diagnosis and interventions: We present a pregnant patient treated with the C5-inhibitor eculizumab due to high risk of developing devastating APS-related complications. The complement inhibitory effects of the treatment were examined both in the patient and the premature infant. Outcomes: Complement activity in the mother recovered considerably faster than anticipated; however, no new thrombosis or CAPS developed during the last week of pregnancy or postpartum. Blood sampling from the umbilical vein and artery, and from the infant after delivery showed low complement activity; however, only 0.3% of the eculizumab concentration detected in the mother, consistent with low placental passage of eculizumab. Lessons: The data underscore the importance of close monitoring of complement inhibition and individualizing dosage regimens in pregnant patients receiving eculizumab. We document how traditional functional complement activity tests cannot assess the effect of eculizumab in premature infants due to the very low levels of complement factors detected in this infant born in gestational week 33. Only trace amounts of eculizumab passed the placenta. In conclusion, complement C5 inhibition might be a safe candidate treatment option for APS during pregnancy and delivery, and additionally, enables prolongation of pregnancy with important weeks.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Skattum, LillemorLund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mig-lsk (författare)
  • Bergseth, GretheUiT The Arctic University of Norway, Tromsø (författare)
  • Lorentzen, BjorgOslo university hospital (författare)
  • Floisand, YngvarOslo university hospital (författare)
  • Bosnes, VidarOslo university hospital (författare)
  • Mollnes, Tom EirikNorwegian Radium Hospital,UiT The Arctic University of Norway, Tromsø,Norwegian University of Science and Technology (författare)
  • Barratt-Due, AndreasOslo university hospital,Norwegian Radium Hospital (författare)
  • Norwegian Radium HospitalInstitutionen för laboratoriemedicin (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Medicine96:110025-7974

Internetlänk

Hitta via bibliotek

  • Medicine (Sök värdpublikationen i LIBRIS)

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