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The association bet...
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Kar, Siddhartha P.University of Cambridge
(författare)
The association between weight at birth and breast cancer risk revisited using Mendelian randomisation
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-02-08
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Springer Science and Business Media LLC,2019
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:8d406351-5fed-47a3-b49f-559536a74574
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https://lup.lub.lu.se/record/8d406351-5fed-47a3-b49f-559536a74574URI
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https://doi.org/10.1007/s10654-019-00485-7DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140835876URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 −8 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. BW predicted by the 41-SNP IV was not associated with overall breast cancer risk in inverse-variance weighted (IVW) univariable MR analysis of genetic association data from 122,977 breast cancer cases and 105,974 controls (odds ratio = 0.86 per 500 g higher BW; 95% confidence interval 0.73–1.01). Sensitivity analyses using four alternative methods and three alternative IVs, including an IV with 59 of the 60 BW-associated SNPs, yielded similar results. Multivariable MR adjusting for the effects of the 49-SNP IV on birth length, adult height, adult body mass index, age at menarche, and age at menopause using IVW and MR-Egger methods provided estimates consistent with univariable analyses. Results were also similar when all analyses were repeated after restricting to estrogen receptor-positive or -negative breast cancer cases. Point estimates of the odds ratios from most analyses performed indicated an inverse relationship between genetically-predicted BW and breast cancer, but we are unable to rule out an association between the non-genetically-determined component of BW and breast cancer. Thus, genetically-predicted higher BW was not associated with an increased risk of breast cancer in adult life in our MR study.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Andrulis, Irene L.University of Toronto,Mount Sinai Hospital of University of Toronto
(författare)
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Brenner, HermannNational Centre of Tumor Diseases,German Cancer Research Centre
(författare)
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Burgess, StephenUniversity of Cambridge
(författare)
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Chang-Claude, JennyGerman Cancer Research Centre,University Medical Center Hamburg-Eppendorf
(författare)
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Considine, DanielUniversity of Cambridge
(författare)
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Dörk, ThiloHannover Medical School
(författare)
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Evans, Dafydd Gareth R.University of Manchester
(författare)
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Gago-Domínguez, ManuelaUniversity of California, San Diego,Complejo Hospitalario Universitario de Santiago,University of Santiago de Compostela
(författare)
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Giles, Graham G.University of Melbourne,Cancer Council Victoria
(författare)
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Hartman, MikaelNational University of Singapore
(författare)
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Huo, DezhengUniversity of Chicago
(författare)
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Kaaks, RudolfGerman Cancer Research Centre
(författare)
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Li, JingmeiA*Star, Genome Institute of Singapore (GIS)
(författare)
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Lophatananon, ArtitayaUniversity of Manchester
(författare)
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Margolin, SaraKarolinska Institutet,Karolinska Institute,Stockholm South General Hospital
(författare)
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Milne, Roger L.University of Melbourne,Cancer Council Victoria
(författare)
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Muir, Kenneth R.University of Manchester
(författare)
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Olsson, HåkanLund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups(Swepub:lu)onk-hol
(författare)
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Punie, KevinCatholic University of Leuven,University Hospitals Leuven
(författare)
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Radice, PaoloIstituto Nazionale dei Tumori
(författare)
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Simard, JacquesCentre hospitalier universitaire de Québec,Laval University
(författare)
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Tamimi, Rulla M.Harvard University,Brigham and Women's Hospital / Harvard Medical School
(författare)
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Van Nieuwenhuysen, ElsCatholic University of Leuven,University Hospitals Leuven
(författare)
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Wendt, CamillaKarolinska Institute,Stockholm South General Hospital
(författare)
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Zheng, WeiVanderbilt University
(författare)
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Pharoah, Paul D.P.University of Cambridge
(författare)
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University of CambridgeUniversity of Toronto
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Epidemiology: Springer Science and Business Media LLC34:6, s. 591-6000393-29901573-7284
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Kar, Siddhartha ...
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Andrulis, Irene ...
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Brenner, Hermann
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Burgess, Stephen
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Chang-Claude, Je ...
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Considine, Danie ...
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visa fler...
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Dörk, Thilo
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Evans, Dafydd Ga ...
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Gago-Domínguez, ...
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Giles, Graham G.
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Hartman, Mikael
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Huo, Dezheng
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Kaaks, Rudolf
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Li, Jingmei
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Lophatananon, Ar ...
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Margolin, Sara
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Milne, Roger L.
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Muir, Kenneth R.
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Olsson, Håkan
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Punie, Kevin
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Radice, Paolo
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Simard, Jacques
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Tamimi, Rulla M.
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Van Nieuwenhuyse ...
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Wendt, Camilla
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Zheng, Wei
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Pharoah, Paul D. ...
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