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Total desmosines in...
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Lindberg, C A
(författare)
Total desmosines in plasma and urine correlate with lung function.
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-09-29
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European Respiratory Society (ERS),2011
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:9a3d8fd1-4359-4594-b311-6b4ab30e5591
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https://lup.lub.lu.se/record/2200887URI
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https://doi.org/10.1183/09031936.00064611DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124335672URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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To evaluate the relationship between the matrix degradation biomarkers, desmosine and isodesmosine (desmosines), and lung function.Plasma and creatinine-corrected urinary total desmosines (P- and U-desmosines), lung function and carbon monoxide diffusion capacity (DL,CO) were measured in a cohort of subjects from the Swedish Twin Registry.Concentrations of U- and P-desmosines were measured in 349 and 318 subjects, respectively; approximately one-third of subjects had chronic obstructive pulmonary disease (COPD). Age, female gender, body mass index (BMI) and smoking were significantly associated with U-desmosines in a multiple linear regression analysis. In the overall population, after adjustments for age, gender, height, BMI and smoking, concentrations of U-desmosines were significantly correlated with all lung function measures, and P-desmosines with forced expiratory volume in 1 s and DL,CO (P<0.05). With the exception of residual volume versus P-desmosines, relationships between concentrations of desmosines and lung function measures were markedly stronger in subjects with COPD compared with those without COPD.These cross-sectional data showing associations between desmosines and several lung function variables suggest that desmosines, particularly U-desmosines, could be a useful biomarker of COPD status.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Engström, G
(författare)
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Gerhardsson de Verdier, M
(författare)
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Nihlén, UlfLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)lung-uni
(författare)
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Anderson, MKarolinska Institutet
(författare)
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Forsman-Semb, K
(författare)
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Svartengren, MKarolinska Institutet
(författare)
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Lungmedicin, allergologi och palliativ medicinSektion II
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Respiratory Journal: European Respiratory Society (ERS)1399-30030903-1936
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