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Association between...
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Kjeldsted, EvaDanish Cancer Society,Naestved Hospital
(författare)
Association between human papillomavirus status and health-related quality of life in oropharyngeal and oral cavity cancer survivors
- Artikel/kapitelEngelska2020
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LIBRIS-ID:oai:lup.lub.lu.se:c1868e67-596e-41e6-8907-cfa978d76921
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https://lup.lub.lu.se/record/c1868e67-596e-41e6-8907-cfa978d76921URI
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https://doi.org/10.1016/j.oraloncology.2020.104918DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Objectives: The human papillomavirus (HPV) is a risk factor for a subgroup of head and neck cancers (HNC). HPV-positive and HPV-negative HNC patients encompass heterogeneous groups regarding risk factors, sociodemographic and clinical characteristics, which may influence health-related quality of life (HRQL) differently. Since this has been sparsely studied, our study investigated the association between HPV status and HRQL in HNC survivors in Denmark. Materials and methods: This cross-sectional study included 179 recurrence-free oropharyngeal and oral cavity squamous cell carcinoma (OSCC) survivors. HRQL was assessed on the EORTC QLQ-C30 and QLQ-H&N35 questionnaires. Linear and logistic regression models were adjusted for sociodemographic, clinical and lifestyle factors. Results: Most unadjusted results showed better HRQL among HPV-positive (n = 119) compared to HPV-negative (n = 60) OSCC survivors (average 18 months since diagnosis). After adjustments, the HPV-positive survivors reported higher role functioning (mean difference [MD] 9.2, 95% confidence interval [CI] 0.1 to –18.4), and fewer problems with speech (MD −9.0, 95% CI −18.0 to −0.1), sexuality (MD −21.9, 95% CI −38.0 to −5.9) and opening mouth (MD −13.7, 95% CI −26.6 to −0.8) compared to HPV-negative survivors. Conclusion: Our findings support that HPV-positive OSCC survivors experience better HRQL than HPV-negative survivors. However, results indicate that sociodemographic, clinical and lifestyle factors explain most of the association between HPV status and HRQL. Findings suggest increased focus on the HPV-negative OSCC survivors with deteriorated HRQL in rehabilitation programs and future research to investigate the long-term effects of treatment among HPV-positive OSCC survivors who may develop symptoms later in survivorship.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Dalton, Susanne OksbjergDanish Cancer Society,Naestved Hospital
(författare)
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Frederiksen, KirstenDanish Cancer Society
(författare)
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Andersen, EloHerlev Hospital,University of Copenhagen
(författare)
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Nielsen, Anni LinnetUniversity of Copenhagen,Herlev Hospital
(författare)
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Stafström, MartinLund University,Lunds universitet,Socialmedicin och global hälsa,Forskargrupper vid Lunds universitet,Social Medicine and Global Health,Lund University Research Groups(Swepub:lu)smi-mst
(författare)
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Kjaer, Trille KristinaDanish Cancer Society
(författare)
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Danish Cancer SocietyNaestved Hospital
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Oral Oncology: Elsevier BV1091368-8375
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