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Sökning: onr:"swepub:oai:lup.lub.lu.se:d1ca89b2-77bf-48eb-9596-66b352d16ef9" > Persistent organic ...

  • Björvang, Richelle D.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)

Persistent organic pollutants and the size of ovarian reserve in reproductive-aged women

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:d1ca89b2-77bf-48eb-9596-66b352d16ef9
  • https://lup.lub.lu.se/record/d1ca89b2-77bf-48eb-9596-66b352d16ef9URI
  • https://doi.org/10.1016/j.envint.2021.106589DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147244201URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Industrial chemicals such as persistent organic pollutants (POPs) have been associated with reduced fertility in women, including longer time-to-pregnancy (TTP), higher odds for infertility, and earlier reproductive senescence. Fertility is highly dependent on the ovarian reserve, which is composed of a prenatally determined stock of non-growing follicles. The quantity and quality of the follicles decline with age, thereby eventually leading to menopause. In the clinical setting, assessing ovarian reserve directly through the histological analysis of follicular density in ovaries is not practical. Therefore, surrogate markers of ovarian reserve, such as serum anti-Müllerian hormone (AMH) are typically used. Here, we studied associations between chemical exposure and ovarian reserve in a cohort of pregnant women undergoing elective caesarean section (n = 145) in Stockholm, Sweden. Full data (histological, clinical, serum) were available for 50 women. We estimated the size of the reserve both directly by determining the density of follicles in ovarian cortical tissue samples, and indirectly by measuring AMH in associated serum samples. Concentrations of 9 organochlorine pesticides (OCPs), 10 polychlorinated biphenyls (PCBs), 3 polybrominated diphenylethers (PBDEs) and 9 perfluoroalkyl substances (PFAS) were determined in serum, and clinical data were retrieved from electronic medical records. Healthy follicle densities (median 0, range 0–193 follicles/mm3) and AMH levels (median 2.33 ng/mL, range 0.1–14.8 ng/mL) varied substantially. AMH correlated with the density of growing follicles. Twenty-three chemicals detected in more than half of the samples were included in the analyses. None of the chemicals, alone or as a mixture, correlated with AMH, growing or atretic follicles. However, HCB, transnonachlor, PCBs 74 and 99 were associated with decreased non-growing follicle densities. HCB and transnonachlor were also negatively associated with healthy follicle density. Further, mixture of lipophilic POPs (PBDE 99, p,p’-DDE, and PCB 187) was associated with lower non-growing follicle densities. In addition, exposure to HCB, p,p’-DDE, and mixture of OCPs were significantly associated with higher odds of infertility. The results suggest that exposure to chemicals may reduce the size of ovarian reserve in humans, and strongly encourage to study mechanisms behind POP-associated infertility in women in more detail.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hassan, JasminKarolinska Institute,Karolinska University Hospital (författare)
  • Stefopoulou, MariaKarolinska Institute,Karolinska University Hospital (författare)
  • Gemzell-Danielsson, KristinaKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
  • Pedrelli, MatteoKarolinska Institutet,Karolinska Institute (författare)
  • Kiviranta, HannuFinnish National Institute for Health and Welfare (författare)
  • Rantakokko, PanuFinnish National Institute for Health and Welfare (författare)
  • Ruokojärvi, PäiviFinnish National Institute for Health and Welfare (författare)
  • Lindh, Christian H.Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-cli (författare)
  • Acharya, GaneshKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
  • Damdimopoulou, PauliinaKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
  • Karolinska InstituteKarolinska University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environment International: Elsevier BV1550160-41201873-6750

Internetlänk

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