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- Avdic, UnaLund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Inflammation and Stemcell Therapy Group,Forskargrupper vid Lunds universitet,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups (författare)
Nonconvulsive status epilepticus in rats leads to brain pathology
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
- 2018-04-10
- Wiley,2018
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:ef01faf4-a657-454e-b2c5-7af9246162df
- https://lup.lub.lu.se/record/ef01faf4-a657-454e-b2c5-7af9246162dfURI
- https://doi.org/10.1111/epi.14070DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- Objective: Status epilepticus (SE) is an abnormally prolonged epileptic seizure that if associated with convulsive motor symptoms is potentially life threatening for a patient. However, 20%-40% of patients with SE lack convulsive events and instead present with more subtle semiology such as altered consciousness and less motor activity. Today, there is no general consensus regarding to what extent nonconvulsive SE (NCSE) is harmful to the brain, which adds uncertainty to stringent treatment regimes. Methods: Here, we evaluated brain pathology in an experimental rat and mouse model of complex partial NCSE originating in the temporal lobes with Western blot analysis, immunohistochemistry, and ex vivo diffusion tensor imaging (DTI). The NCSE was induced by electrical stimulation with intrahippocampal electrodes and terminated with pentobarbital anesthesia. Video-electroencephalographic recordings were performed throughout the experiment. Results: DTI of mice 7 weeks post-NCSE showed no robust long-lasting changes in fractional anisotropy within the hippocampal epileptic focus. Instead, we found pathophysiological changes developing over time when measuring protein levels and cell counts in extracted brain tissue. At 6 and 24 hours post-NCSE in rats, few changes were observed within the hippocampus and cortical or subcortical structures in Western blot analyses of key components of the cellular immune response and synaptic protein expression, while neurodegeneration had started. However, 1 week post-NCSE, both excitatory and inhibitory synaptic protein levels were decreased in hippocampus, concomitant with an excessive microglial and astrocytic activation. At 4 weeks, a continuous immune response in the hippocampus was accompanied with neuronal loss. Levels of the excitatory synaptic adhesion molecule N-cadherin were decreased specifically in rats that developed unprovoked spontaneous seizures (epileptogenesis) within 1 month following NCSE, compared to rats only exhibiting acute symptomatic seizures within 1 week post-NCSE. Significance: These findings provide evidence for a significant brain pathology following NCSE in an experimental rodent model.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Diffusion tensor imaging
- Inflammation
- N-cadherin
- Nonconvulsive status epilepticus
- Synaptic proteins
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Ahl, MatildaLund University,Lunds universitet,Inflammation and Stemcell Therapy Group,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)ma1011ah (författare)
- Chugh, DeeptiLund University,Lunds universitet,Inflammation and Stemcell Therapy Group,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-dtc (författare)
- Ali, IdrishLund University,Lunds universitet,Inflammation and Stemcell Therapy Group,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-iia (författare)
- Chary, KarthikUniversity of Eastern Finland (författare)
- Sierra, AlejandraUniversity of Eastern Finland (författare)
- Ekdahl, Christine T.Lund University,Lunds universitet,Inflammation and Stemcell Therapy Group,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)neur-cek (författare)
- EpilepsicentrumSektion IV (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Epilepsia: Wiley59:5, s. 945-9580013-95801528-1167
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