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Replicability and r...
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Rietveld, CAErasmus University (NL)
(author)
Replicability and robustness of genome-wide-association studies for behavioral traits
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-10-06
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SAGE Publications,2014
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:130117743
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130117743URI
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https://doi.org/10.1177/0956797614545132DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239575URI
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https://research.hhs.se/esploro/outputs/journalArticle/Replicability-and-Robustness-of-Genome-Wide-Association-Studies/991001480310106056URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A recent genome-wide-association study of educational attainment identified three single-nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each R2 ≈ 0.02%), reached genome-wide significance ( p < 5 × 10−8) in a large discovery sample and were replicated in an independent sample ( p < .05). The study also reported associations between educational attainment and indices of SNPs called “polygenic scores.” In three studies, we evaluated the robustness of these findings. Study 1 showed that the associations with all three SNPs were replicated in another large ( N = 34,428) independent sample. We also found that the scores remained predictive ( R2 ≈ 2%) in regressions with stringent controls for stratification (Study 2) and in new within-family analyses (Study 3). Our results show that large and therefore well-powered genome-wide-association studies can identify replicable genetic associations with behavioral traits. The small effect sizes of individual SNPs are likely to be a major contributing factor explaining the striking contrast between our results and the disappointing replication record of most candidate-gene studies.
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Conley, DNew York University
(author)
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Eriksson, N23andMe
(author)
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Esko, TUniversity of Tartu
(author)
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Medland, SEQueensland Institute of Medical Research
(author)
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Vinkhuyzen, AAEUniversity of Queensland (AU)
(author)
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Yang, JUniversity of Queensland (AU),23andMe
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Boardman, JDUniversity of Colorado
(author)
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Chabris, CFUnion College (US)
(author)
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Dawes, CTNew York University
(author)
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Domingue, BWUniversity of Colorado
(author)
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Hinds, DA23andMe
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Johannesson, MagnusStockholm School of Economics,Handelshögskolan i Stockholm(Swepub:hhs)198@hhs.se
(author)
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Kiefer, AK23andMe
(author)
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Laibson, DHarvard University (US)
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Magnusson, PKEKarolinska Institutet,Karolinska Institutet (SE)
(author)
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Mountain, JL23andMe
(author)
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Oskarsson, SvenUppsala universitet,Statsvetenskapliga institutionen,Uppsala University (SE)(Swepub:uu)sos20331
(author)
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Rostapshova, OHarvard University (US)
(author)
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Teumer, AGreifswald Medical School
(author)
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Tung, JY
(author)
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Visscher, PMUniversity of Queensland (AU)
(author)
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Benjamin, DJCornell University (US)
(author)
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Cesarini, DCenter for Experimental Social Science
(author)
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Koellinger, PDErasmus School of Economics (NL)
(author)
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Erasmus University (NL)New York University
(creator_code:org_t)
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In:Psychological science: SAGE Publications25:11, s. 1975-19861467-92800956-7976
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Rietveld, CA
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Conley, D
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Eriksson, N
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Esko, T
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Medland, SE
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Vinkhuyzen, AAE
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Yang, J
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Boardman, JD
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Chabris, CF
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Dawes, CT
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Domingue, BW
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Hinds, DA
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Johannesson, Mag ...
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Kiefer, AK
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Laibson, D
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Magnusson, PKE
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Mountain, JL
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Oskarsson, Sven
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Rostapshova, O
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Teumer, A
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Tung, JY
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Visscher, PM
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Benjamin, DJ
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Cesarini, D
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Koellinger, PD
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Karolinska Institutet
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